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Oculomotor Abnormalities in Anti-Glutamic Acid Decarboxylase-Positive Stiff Person Syndrome [PDF]
Neurology InternationalBackground: Antibodies to glutamic acid decarboxylase (anti-GAD) can give rise to stiff person syndrome (SPS), an infrequent autoimmune condition of the central nervous system marked by fluctuating muscular rigidity and stimulus-evoked spasms ...
Pavol Skacik +6 more
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Stiff Person Syndrome Associated with Compartment Syndrome [PDF]
Case Reports in Neurology, 2019 Stiff person syndrome (SPS) is a rare and disabling neurological disorder of autoimmune origin, characterized by progressive stiffness and muscle spasms affecting the axial and limb muscles, most frequently associated with antibodies against glutamic ...
Kok Pin Yong, Yew Long Lo
doaj +2 more sources
Practical Neurology, 2011 Stiff person syndrome (SPS) is a rare disorder, characterised by fluctuating rigidity and stiffness of the axial and proximal lower limb muscles, with superimposed painful spasms and continuous motor unit activity on electromyography. Although rare in general neurology practice, once observed it is unforgettable.
Claudia Sommer, Franco Folli
+7 more sources
Stiff person syndrome (SPS): Literature review and case report
South African Journal of Psychiatry, 2013 Stiff person syndrome (SPS) is a rare, debilitating condition which presents with progressive and inconsistent neurological features. The main symptoms are stiffness and intermittent, painful muscle spasms, triggered and exacerbated by stressful and ...
Erna Pretorius, Wilmarie Struwig
doaj +3 more sources
Annals of Indian Academy of Neurology, 2016 Antibodies to GAD-65 have been implicated in the pathogenesis of type 1 diabetes , limbic encephalitis and Stiff person syndrome, however these diseases rarely occur concurrently.
Chandra Mohan Sharma +4 more
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Stiff-Person Syndrome: Case Series [PDF]
Journal of Movement Disorders, 2014 Stiff-person syndrome (SPS) is a rare disorder, characterized by progressive fluctuating muscular rigidity and spasms. Glutamic acid decarboxylase (GAD) antibody is primarily involved in the pathogenesis of SPS and SPS is strongly associated with other ...
Yu Jin Jung +4 more
doaj +3 more sources
Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions [PDF]
Frontiers in Behavioral Neuroscience, 2015 Autoantibodies to the smaller isoform of glutamate decarboxylase can be found in patients with type 1 diabetes and a number of neurological disorders, including stiff-person syndrome, cerebellar ataxia and limbic encephalitis.
Mario U Manto +10 more
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Case report of stiff - person syndrome and literature review [PDF]
IBRO Neuroscience ReportsObjective: Currently, there is no objective evaluation method to measure muscle tension and therapeutic effects in patients with stiff person syndrome (SPS). We aimed to investigate objective evaluation criteria for diagnosis and treatment.
Qiongfang Zhang +5 more
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Anti-glutamic acid decarboxylase 65: Related stiff person syndrome – A report of two cases and literature review [PDF]
SAGE Open Medical Case ReportsStiff person syndrome is a rare neurological disorder characterized by muscular rigidity, painful spasms, and gait abnormalities. The diagnosis is primarily clinical and often requires a high index of suspicion.
Ena Elizabeth L. Naoe +3 more
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S.S. Korsakov Journal of Neurology and PsychiatryStiff-person syndrome is a rare autoimmune disorder manifested by stiffness in the trunk and proximal limb muscles and painful muscle spasms in them. The disease is associated with the production of glutamate decarboxylase autoantibodies, an enzyme converting glutamate into gamma-aminobutyric acid. An increase of anti-GAD antibody serum levels above 10.
Muranova A, Shanina E.
europepmc +9 more sources