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Stiff-Person Syndrome: Case Series [PDF]
Journal of Movement Disorders, 2014 Stiff-person syndrome (SPS) is a rare disorder, characterized by progressive fluctuating muscular rigidity and spasms. Glutamic acid decarboxylase (GAD) antibody is primarily involved in the pathogenesis of SPS and SPS is strongly associated with other ...
Yu Jin Jung +4 more
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Practical NeurologyStiff Person syndrome (SPS) is a rare autoimmune disorder of the central nervous system characterized by stiffness and spasms in the lumbar and proximal lower limb muscles. Nonmotor symptoms include phobias, anxiety, and depression. SPS exists on a spectrum ranging from a focal disease known as the stiff limb syndrome to progressive encephalomyelitis ...
Muranova A, Shanina E.
europepmc +10 more sources
Anti-glutamic acid decarboxylase 65: Related stiff person syndrome – A report of two cases and literature review [PDF]
SAGE Open Medical Case ReportsStiff person syndrome is a rare neurological disorder characterized by muscular rigidity, painful spasms, and gait abnormalities. The diagnosis is primarily clinical and often requires a high index of suspicion.
Ena Elizabeth L. Naoe +3 more
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Stiff Person Syndrome Associated with Compartment Syndrome [PDF]
Case Reports in Neurology, 2019 Stiff person syndrome (SPS) is a rare and disabling neurological disorder of autoimmune origin, characterized by progressive stiffness and muscle spasms affecting the axial and limb muscles, most frequently associated with antibodies against glutamic ...
Kok Pin Yong, Yew Long Lo
doaj +3 more sources
Case report of stiff - person syndrome and literature review [PDF]
IBRO Neuroscience ReportsObjective: Currently, there is no objective evaluation method to measure muscle tension and therapeutic effects in patients with stiff person syndrome (SPS). We aimed to investigate objective evaluation criteria for diagnosis and treatment.
Qiongfang Zhang +5 more
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The many faces of gastrointestinal dysfunction in stiff person syndrome spectrum disorders
Frontiers in Neurology, 2023 IntroductionThe effect of stiff person syndrome spectrum disorders (SPSD) on the gastrointestinal tract (GIT) is unknown. This case series aims to characterize the prevalence and types of GI dysfunction in individuals with SPSD.MethodsA retrospective ...
Jacqueline Koshorek +10 more
doaj +3 more sources
Polycythemia vera and stiff-person syndrome: a case report [PDF]
BMC NeurologyBackground Polycythemia vera (PV) is a myeloproliferative neoplasm, characterized by trilineage hypercellularity, which increases the risk of thrombosis.
Haixia Mu +8 more
doaj +2 more sources
Oculomotor Abnormalities in Anti-Glutamic Acid Decarboxylase-Positive Stiff Person Syndrome [PDF]
Neurology InternationalBackground: Antibodies to glutamic acid decarboxylase (anti-GAD) can give rise to stiff person syndrome (SPS), an infrequent autoimmune condition of the central nervous system marked by fluctuating muscular rigidity and stimulus-evoked spasms ...
Pavol Skacik +6 more
doaj +2 more sources
Proposing Bromo-Epi-Androsterone (BEA) for Stiff Person Syndrome (SPS) [PDF]
MicroorganismsSPS is characterized by progressive spasmodic muscular rigidity. SPS is thought to be an autoimmune disease with a prominent feature of antibodies against glutamic acid decarboxylase (GAD). GAD is responsible for the enzymatic conversion of glutamic acid
Coad Thomas Dow
doaj +2 more sources
Late-onset stiff-person syndrome: challenges in diagnosis and management
Therapeutic Advances in Neurological Disorders, 2023 Background: Stiff person syndrome (SPS) is a rare slowly progressive autoimmune neuronal hyperexcitability disease with very-high GAD-65 antibody titers that most commonly presents above the age of 20, with muscle stiffness, painful muscle spasms, slow ...
Marinos C. Dalakas, Jessica Yi
doaj +2 more sources