Results 71 to 80 of about 120,633 (286)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
MathematicsPhysics-Informed Neural Networks (PINNs) often struggle with stiff partial differential equations (PDEs) exhibiting sharp gradients and extreme nonlinearities.
Hasan Cetinkaya +6 more
doaj +1 more source
Haar wavelet method for solving stiff differential equations
Mathematical Modelling and Analysis, 2009 Application of the Haar wavelet approach for solving stiff differential equations is discussed. Solution of singular perturbation problems is also considered.
Ülo Lepik
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Survey of Parallel Block Methods [PDF]
مجلة التربية والعلم, 2010 The main purpose of this research is the survey of the development Block parallel numerical algorithms for solute stiff ordinary differential equations which are suitable for running on MIMD (Multiple instruction streams with multiple data streams ...
Bashir M. Khalaf +2 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Linear iterative solvers for implicit ODE methods [PDF]
The numerical solution of stiff initial value problems, which lead to the problem of solving large systems of mildly nonlinear equations are considered.
Saylor, Paul E., Skeel, Robert D.
core +1 more source
The Cardy-Verlinde Formula and Charged Topological AdS Black Holes
, 2001 We consider the brane universe in the bulk background of the charged topological AdS black holes. The evolution of the brane universe is described by the Friedmann equations for a flat or an open FRW-universe containing radiation and stiff matter.
Bekenstein J. D. +7 more
core +3 more sources
The numerical solution of stiff differential equations [PDF]
FEBS Letters, 1969 The separate problem of stability and accuracy in numerical methods of approximating the solution of systems of non‐linear equations is then treated. Stress is laid on the consistently unsatisfactory results given by explicit methods for systems containing “stiff” equations, and implicit multistep methods are particularly recommended for this class of ...
openaire +2 more sources