Results 71 to 80 of about 10,782 (261)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Towards Numerical Method-Informed Neural Networks for PDE Learning
MathematicsSolving stiff partial differential equations with neural networks remains challenging due to the presence of multiple time scales and numerical instabilities that arise during training. This paper addresses these limitations by embedding the mathematical
Pasquale De Luca, Livia Marcellino
doaj +1 more source
Hybrid stars and the stiffness of the nuclear equation of state in light of the HESS J1731-347 remnant [PDF]
EPJ Web of ConferencesThe recent observation of the extremely compact neutron star in the HESS J1731-347 remnant has challenged our understanding concerning the nature of dense nuclear matter.
Laskos-Patkos Pavlos +2 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Mathematics, 2019 In this research, a singly diagonally implicit block backward differentiation formulas (SDIBBDF) for solving stiff ordinary differential equations (ODEs) is proposed.
Saufianim Jana Aksah +2 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
On overcoming Dahlquist’s second barrier for$A$-stable linear multistep methods [PDF]
Iranian Journal of Numerical Analysis and OptimizationDahlquist’s second barrier limits the order of $A$-stable linear multistep methods to at most two, posing significant challenges for achieving higher accuracy in the numerical solution of stiff ordinary differential equations.
G. Hojjati, S. Fazeli, A. Moradi
doaj +1 more source