Results 81 to 90 of about 120,633 (286)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Partitioning Techniques and Their Parallelization for Stiff System of Ordinary Differential Equations [PDF]
, 2007 A new code based on variable order and variable stepsize component wise partitioning is introduced to solve a system of equations dynamically. In previous partitioning technique researches, once an equation is identified as stiff, it will remain in ...
Othman, Khairil Iskandar
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Approximate equations for circular hinge stiffnesses
Transactions of the JSME (in Japanese), 2023 Flexure hinges are widely used for very high precision mechanisms, such as a high precision linear guide, a nano positioning stage, a robot hand and etc., because of no gap and no friction. Regarding circular hinge stiffnesses, Paros and Weisbord derived exact solutions, but they are unwieldly because of the complexity.
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Anisotropic neutron stars in $R^2$ gravity
, 2018 We consider static neutron stars within the framework of $R^2$ gravity. The neutron fluid is described by three different types of realistic equations of state (soft, moderately stiff, and stiff).
Folomeev, Vladimir
core +1 more source
Explicit Methods for Stiff Stochastic Differential Equations [PDF]
, 2011 Multiscale differential equations arise in the modeling of many important problems in the science and engineering. Numerical solvers for such problems have been extensively studied in the deterministic case. Here, we discuss numerical methods for (mean-square stable) stiff stochastic differential equations. Standard explicit methods, as for example the
openaire +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Towards Numerical Method-Informed Neural Networks for PDE Learning
MathematicsSolving stiff partial differential equations with neural networks remains challenging due to the presence of multiple time scales and numerical instabilities that arise during training. This paper addresses these limitations by embedding the mathematical
Pasquale De Luca, Livia Marcellino
doaj +1 more source