Results 141 to 150 of about 3,860 (279)

Simple and detailed modeling of corrosion‐affected slender shear critical RC beams

Structural Concrete, EarlyView.
Abstract The corrosion of steel bars compromises both the safety and the serviceability of reinforced concrete (RC) structures. Consequently, reliable tools are required to estimate the detrimental effects of corrosion on the structural response of RC members subjected to transverse loads.
Nino Spinella, Pier Paolo Rossi
wiley   +1 more source

Experimental and Numerical Investigations of Thin-Walled Stringer-Stiffened Panels Welded with RFSSW Technology under Uniaxial Compression. [PDF]

Materials (Basel), 2019
Kubit A, Trzepiecinski T, Święch Ł, Faes K, Slota J.   +4 more
europepmc   +1 more source

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

British Journal of Pharmacology, EarlyView.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi, Annika A. Jüttner, Annique Claringbould, Rene de Vries, Ingrid M. Garrelds, Usha Musterd‐Bhaggoe, Bruno H. Stricker, Maryam Kavousi, A. H. Jan Danser, Fariba Ahmadizar, Anton J. M. Roks   +10 more
wiley   +1 more source

Fiber Bridging Induced Toughening Effects on the Delamination Behavior of Composite Stiffened Panels under Bending Loading: A Numerical/Experimental Study. [PDF]

Materials (Basel), 2019
Russo A, Zarrelli M, Sellitto A, Riccio A.   +3 more
europepmc   +1 more source

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Strength of Ship Stiffened Panels under Combined Loading

, 2000
A ship's hull is a box girder structure composed of stiffened panels and therefore, strength of stiffened panels plays a significant role for the ultimate strength analysis of ship structures.
Pedersen, Preben Terndrup, Weicheng, Cui, Wang, Young-jun   +2 more
core  

Topology optimization for stiffened panels considering postbuckling

Size and shape optimization has long been studied to maximize the critical buckling load whilst reducing the mass of stiffened panels used extensively in the structures and aerospace sectors.
Chu, S., Kennedy, D., Kim, H. A., Featherston, C. A.   +3 more
core   +1 more source

When proteases reshape barriers: Basement membrane remodelling in development, wound healing and tumour progression

The FEBS Journal, EarlyView.
Basement membrane (BM) homeostasis relies on a balance between integrity, controlled remodelling and pathological degradation. Increased protease expression beneath the BM, along with reduced levels of endogenous protease inhibitors, drives the transition from a continuous, protective barrier to a discontinuous interface.
Clara Legendre, Guila Dayan, Patricia Rousselle   +2 more
wiley   +1 more source

Extracellular fluid viscosity influences the mechanics and migration of MDA‐MB‐231 cells in a macromolecule‐dependent manner

The FEBS Journal, EarlyView.
Macromolecule‐dependent increases in extracellular fluid viscosity alter cell phenotype. These distinct macromolecules create different extracellular environments that modulate cell morphology and mechanoprotein expression, migration and invasion capacity, and cellular mechanical properties.
Ian M. Smith, Nikka Givpoor, Chenchen Handler, Ariel Abraham, Shohini Banerjee, Giuliano Scarcelli, Kimberly M. Stroka   +6 more
wiley   +1 more source