Research on Residual Strength and Evaluation Methods of Metal Aircraft Stiffened Panel Structures with Perforations. [PDF]
Materials (Basel)Ren A, An T, Zhang T, Wang Y, Ma L.
europepmc +1 more source
Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing
Advanced Science, EarlyView.Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan +13 more
wiley +1 more source
Advanced Science, EarlyView.Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu +11 more
wiley +1 more source
Optimization of the grid-stiffened structure via PSO-LSSVR surrogate modeling and sensitivity analysis. [PDF]
Sci RepGai J +5 more
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Advanced Science, EarlyView.A design of double gradient effect is proposed to resolve the contradictory optimization on sensitivity and linearity of piezoresistive tactile sensors. The ultrawide linearity is realized by the sequential trigger of pressure‐induced gradient conductivity‐enabled linear current owing to the gradient microstructures.
Yao Fang +13 more
wiley +1 more source
Numerical Investigation of the Bending, Torsional, and Hydrostatic Pressure Responses of Hybrid Kenaf/Flax/Glass Fiber Composite Shell Structures for Unmanned Maritime Vehicles. [PDF]
Materials (Basel)Huang Y +4 more
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Advanced Science, EarlyView.Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim +2 more
wiley +1 more source
ΜEffect of polymeric foam core morphology and orthogrid stiffener design on the noise attenuation of fluid-immersed structures. [PDF]
Sci RepZafari H, Mardaneh T, Tarkashvand A.
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Quality Thresholds for Angiogenesis Under Acoustic Manipulation in Engineered Vascular Tissues
Advanced Science, EarlyView.Defined biological and physical quality thresholds achieved through acoustic manipulation regulate cellular alignment and spatial organization, promoting self‐assembling vasculature, extracellular matrix deposition, and angiogenic responses, thereby establishing critical acoustic patterning requirements for engineered vascular tissue development in ...
Oscar O'Dwyer Lancaster‐Jones +5 more
wiley +1 more source
Axial strength of back to back cold formed steel short channel sections with unstiffened and stiffened web holes. [PDF]
Sci RepHussein AB, Papp F.
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