Results 21 to 30 of about 379,204 (219)
Design and Simulation of a Titanium Alloy Lattice Bone Plate for 3D Printing
Shanghai Jiaotong Daxue xuebao, 2021 In order to improve the stress shielding effect caused by excessive elastic modulus of metal plates during fracture healing, a kind of 3D printing oriented lattice structure plate is designed based on topology optimization and the finite element modeling
ZHANG Cong +4 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Frontiers in Oncology, 2022 BackgroundConventional ultrasound diagnosis of thyroid nodules (TNs) had a high false-positive rate, resulting in many unnecessary fine-needle aspirations (FNAs).ObjectiveThis study aimed to establish a simple algorithm to reduce unnecessary FNA on ...
Xiao Liu +5 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Sensitivity Analysis of Fastenings’ Types on Track\'s Life-Cycle [PDF]
International Journal of Railway Research, 2014 During the study for the dimensioning as well as the selection of the individual materials constituting a railway track, the ballast and the substructure present residual deformations, directly related to the deterioration of the geometry of the track.
Konstantinos Giannakos
doaj
Quantification of the stiffness and strength of cadherin ectodomain binding with different ions
Theoretical and Applied Mechanics Letters, 2014 The stiffness and strength of extracellular (EC) region of cadherin are proposed to be two important mechanical properties both for cadherin as a mechanotransductor and for the formation of cell-cell adhesion.
Zhiyang Xu, Dechang Li, Ji Baohua
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Frontiers in Physiology, 2021 Increased muscle stiffness can contribute to reduced range of motion (ROM) and impaired function. Reduced ankle dorsiflexion ROM has been associated with increased injury risk in the ankle.
Tian-Tian Chang +5 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source