Results 51 to 60 of about 1,105,625 (354)

A Nonlinear Model of Mix Coil Spring – Rubber for Vertical Suspension of Railway Vehicle

open access: yesArchive of Mechanical Engineering, 2016
The paper focuses on a nonlinear model to represent the mechanical behaviour of a mix coil spring - rubber used in the secondary suspension of passenger rail vehicles.
Dumitriu Mădălina
doaj   +1 more source

Hierarchies of plant stiffness [PDF]

open access: yesPlant Science, 2016
Plants must meet mechanical as well as physiological and reproductive requirements for survival. Management of internal and external stresses is achieved through their unique hierarchical architecture. Stiffness is determined by a combination of morphological (geometrical) and compositional variables that vary across multiple length scales ranging from
Veronique Brulé   +3 more
openaire   +3 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

The stiff man and stiff man plus syndromes

open access: yesJournal of Neurology, 1999
Rigidity in the setting of continuous motor unit activity at rest can be caused by a variety of central and peripheral conditions. A central origin is suggested by the presence of painful reflex spasms. Focal spinal lesions and infective causes are relatively easily excluded through imaging, microbiological and serological studies.
Brown, P, Marsden, C
openaire   +4 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Comparison of Three Stiffness Testers [PDF]

open access: yes, 1951
Stiffness is defined and some of the factors affecting stiffness are given. Also, the underlying principles upon which most stiffness testers are based are given. Three of the commonly used stiffness instruments are used for this comparison study.
Anderson, Arne H.
core   +1 more source

Arterial Stiffness [PDF]

open access: yesPulse, 2013
Stiffness of large arteries has been long recognized as a significant determinant of pulse pressure. However, it is only in recent decades, with the accumulation of longitudinal data from large and varied epidemiological studies of morbidity and mortality associated with cardiovascular disease, that it has emerged as an independent predictor of ...
openaire   +2 more sources

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

open access: yesMolecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Stiffness Effects of Structural Elements on the Seismic Response of RC High-Rise Buildings

open access: yesArchives of Civil Engineering, 2018
The stiffness of structural elements (columns, beams, and slabs) significantly contributes to the overall stiffness of reinforced concrete (RC) high-rise buildings (H.R.B.s) subjected to earthquake.
Kontoni D.-P. N., Farghaly A. A.
doaj   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

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