Results 51 to 60 of about 768,686 (296)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Free vibration of a three-layered sandwich beam using the dynamic stiffness method and experiment [PDF]

, 2007
In this paper, an accurate dynamic stiffness model for a three-layered sandwich beam of unequal thicknesses is developed and subsequently used to investigate its free vibration characteristics.
Banerjee, J. R., Cheung, C. W., Morishima, Ryoko, Njuguna, James A., Perera, Melanie   +4 more
core   +1 more source

Shock isolation using switchable stiffness

, 2008
This study investigates a novel stiffness control strategy applied to the problem of shock isolation. This is based on the principle that the stiffness and mass are the principal physical properties that control the passive system shock response.
Ledezma Ramirez, Diego Francisco
core   +1 more source

Nanoparticles: Strained and Stiff [PDF]

Science, 2004
Nanoparticles may contain unusual forms of structural disorder that can substantially modify materials properties and thus cannot solely be considered as small pieces of bulk material. We have developed a method to quantify intermediate-range order in 3.4-nanometer-diameter zinc sulfide nanoparticles and show that structural coherence is lost over ...
Gilbert, Benjamin, Huang, Feng, Zhang, Hengzhong, Waychunas, Glenn A., Banfield, Jillian F.   +4 more
openaire   +3 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Concentric left ventricular remodeling and aortic stiffness: a comparison of obesity and hypertension. [PDF]

, 2013
BACKGROUND: Increased thoracic ascending aortic stiffness is thought to contribute to concentric left ventricular hypertrophy and increased mortality, a pattern seen in hypertension.
Francis, JM, Rider, OJ, Nethononda, R, Petersen, SE, Neubauer, Stefan, Francis, Jane M., Rider, Oliver J., Petersen, Steffen E., Neubauer, S, Nethononda, Richard, Clarke, Kieran, Byrne, James, Clarke, K, Byrne, JP, Leeson, P, Leeson, Paul   +15 more
core   +1 more source

Hierarchies of plant stiffness [PDF]

Plant Science, 2016
Plants must meet mechanical as well as physiological and reproductive requirements for survival. Management of internal and external stresses is achieved through their unique hierarchical architecture. Stiffness is determined by a combination of morphological (geometrical) and compositional variables that vary across multiple length scales ranging from
Veronique Brulé, Ahmad Rafsanjani, Damiano Pasini, Tamara L. Western   +3 more
openaire   +2 more sources

Wrist and forearm rotation of the DLR Hand Arm System: Mechanical design, shape analysis and experimental validation [PDF]

, 2011
The DLR Hand Arm System is based upon the variable stiffness concept which has been recently developed to improve impact robustness and energy efficiency of modern robots. This paper continues the work on the bidirectional antagonistic variable stiffness
F. Petit, Friedl, Werner, Höppner, Hannes, W. Friedl, Petit , Florian, Gerd, Hirziner, H. Hoppner, G. Hirzinger   +7 more
core   +1 more source