Results 91 to 100 of about 18,883 (250)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

NEW INSIGHTS INTO THE HORSE STIFLE JOINT THROUGH 3D COMPUTED TOMOGRAPHY, SCANNING ELECTRON MICROSCOPY, AND SCANNING ELECTRON MICROSCOPY-ENERGY DISPERSIVE X-RAY ANALYSIS

Slovenian Veterinary Research
The study design was prospective and descriptive of the horse stifle joint using CT, sectional anatomy, SEM, and EDX analysis. The 3D rendered-volume reconstruction CT of the horse's stifle joint allows good visualization of the large and small bony ...
Mohamed A. M. Alsafy, Ahmed K. S. El-Garhy, Ismail Abo-Ghanima, Ahmed G. Nomir, Samir A. A. El-Gendy   +4 more
doaj   +1 more source

Photomicrographs of stifle synovium from dogs with unilateral cranial cruciate ligament rupture and a contralateral stable stifle.

, 2013
(A) Unstable stifle of a five-year-old neutered male Golden Retriever. Proliferation of the synovial intima with villus formation can be seen. Widening of intima (arrows) and infiltration of the intima and sub-intima with mononuclear inflammatory cells ...
Abigail Kreines (342550), Zhengling Hao (308207), Gerianne Holzman (342555), Sady Y. Cabrera (342551), Susan L. Schaefer (342554), Zeev Schwartz (342548), Nicole J. Buote (342552), Sarah Malek (342549), Jason A. Bleedorn (342553), Peter Muir (308211)   +9 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Three-Dimensional-Printed Thermoplastic Polyurethane (TPU) Graft and H-Button Stabilization System for Intra-Articular Cranial Cruciate Ligament Reconstruction: Cadaveric Study

Veterinary Sciences
Cranial cruciate ligament (CrCL) rupture is a common orthopedic disorder in dogs, leading to stifle joint instability and progressive osteoarthritis. This study aimed to develop and biomechanically evaluate a novel intra-articular reconstruction system ...
Menna Nahla, Yara Abouelela, Mohammed Amer, Marwa Ali, Abdelbary Prince, Ayman Tolba, Ayman Mostafa   +6 more
doaj   +1 more source

Ultrasound anatomy of the normal stifle in the sheep

, 2019
Though the ovine stifle is commonly used as a model in research, there is no description of its anatomy at ultrasonography (US). The objective of this study was to provide reference US images of the ovine stifle that are relevant in musculoskeletal ...
Dugdale, Alex, Hontoir, Fanny, Clegg, Peter, Kirschvink, Nathalie, Kayser, Françoise, Vandeweerd, Jean-Michel   +5 more
core   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Bilateral Functional Tarsal Hyperextension Associated with Stifle Pathology Improved Following Stifle Stabilization in a Dog: A Case Report

Veterinary Sciences
Abnormal tarsal posture in dogs may be associated with structural lesions such as common calcaneal tendon complex rupture, plantar-supporting structure injury, tarsocrural instability, or neurologic dysfunction; however, common calcaneal tendon rupture ...
Woosung Jung, Hyeong-mok Kim, Su-jin Son, Hwi-yool Kim   +3 more
doaj   +1 more source

Ruptura do ligamento cruzado cranial em um gato: reconstituição com fáscia lata Cranial cruciate ligament rupture in a cat: reconstitution with fascia lata

Ciência Rural, 2012
Em gatos, a ruptura do ligamento cruzado cranial (RLCC) trata-se de diagnóstico raro e a correção cirúrgica propicia o retorno mais rápido à função do membro.
Érika Fernanda Villamayor Garcia, João Eduardo Wallau Schossler, Maicon Pinheiro   +2 more
doaj   +1 more source

The Ovine Stifle as a Model for Human Cruciate Ligament Surgery

, 1996
SummaryThis study evaluated the anatomy and biomechanics of the ovine stifle, with a view to its use as a model of the human knee joint.Stifles were dissected to define the internal anatomy, concentrating on the cruciate ligaments.
A. C. Stead, A. A. Amis, W.J.P. Radford
core   +1 more source