Results 81 to 90 of about 18,883 (250)

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Effect of autologous bone marrow-derived mesenchymal stem cell (BM-MSC) treatment on serum and stifle synovial fluid C-reactive protein (CRP) in dogs with cruciate ligament rupture (CR).

, 2016
(A) Median serum CRP concentration was significantly decreased at 4 weeks after MSC treatment, compared with diagnosis. Median serum CRP was also lower at 8 weeks, compared with diagnosis.
Caitlin Heaton (3092496), Susannah J. Sample (308203), Susan L. Schaefer (342554), Ermias Amene (3092493), Eric C. Hans (3092490), Jason A. Bleedorn (342553), Peter Muir (308211), Nicola Volstad (3092487), Debra D. Bloom (3092481), Zhengling Hao (308207), Gerianne Holzman (342555), Peiman Hematti (57312), M. Suresh (14253), Molly Racette (3092484)   +13 more
core   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Stifle arthrodesis in a feline pelvic limb amputee

Journal of Feline Medicine and Surgery Open Reports
Case summary A domestic shorthair cat presented to the Animal Referral Hospital (Brisbane, Australia) after having the left pelvic limb incorrectly amputated.
Wei Tze Goh, Jarrod Drew
doaj   +1 more source

Ex vivo preliminary investigation of radiographic quantitative assessment of cranial tibial displacement at varying degrees of canine stifle flexion with or without an intact cranial cruciate ligament

BMC Veterinary Research, 2018
Background The presence of cranial tibial subluxation can aid in the detection of joint instability as a result of CrCL injury. Detection of cranial tibial subluxation has been described using the tibial compression test (TCT) and cranial drawer test ...
Katrina A. Castaneda, Caleb C. Hudson, Brian S. Beale   +2 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Percutaneous extracapsular repair as a cost-effective alternative for treating cranial cruciate ligament deficiency in dogs

Frontiers in Veterinary Science
ObjectiveTo evaluate the duration of surgery, cost, and outcomes associated with percutaneous placement of a lateral fabellotibial suture (pLFS) in dogs with unilateral cranial cruciate ligament deficiency (CCLD) treated in a low-cost clinical setting ...
Dominique J. Griffon, Ayman Mostafa, Ayman Mostafa, Etienne Griffon, David J. Schaeffer   +4 more
doaj   +1 more source

Additional file 1: of Quantification of three-dimensional soft tissue artifacts in the canine hindlimb during passive stifle motion

, 2018
Linear regression equations for the soft tissue artifacts of the markers. Linear regression equations were computed for marker displacement components greater than 10 mm with the stifle rotation angle as regressor. The stifle rotation is defined as the
Cheng-Chung Lin (6059483), Ching-Ho Wu (6059486), Tung-Wu Lu (560007), Ming Lu (122276), Chia-Lin Chang (2388646)   +4 more
core   +1 more source