Results 61 to 70 of about 105,641 (310)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Artroscopia do joelho de ovinos Arthroscopy of the stifle joint in sheep

Pesquisa Veterinária Brasileira, 2008
O trabalho teve por objetivo avaliar artroscopicamente a articulação do joelho de ovinos hígidos em diferentes idades, com o intuito de determinar, de acordo com os portais estabelecidos, a capacidade de observação das estruturas.
Khadije Hette, Sheila C. Rahal, Reinaldo S. Volpi, Danilo Otávio L. Ferreira, Carlos R. Teixeira   +4 more
doaj   +1 more source

Dynamic Lumbosacral Magnetic Resonance Imaging in a Dog with Tethered Cord Syndrome with a Tight Filum Terminale [PDF]

, 2017
A 1-year and 11-month- old English Cocker Spaniel was evaluated for clinical signs of progressive right pelvic limb lameness and urinary incontinence. Neurological examination was suggestive of a lesion localized to the L4–S3 spinal cord segments.
De Decker, De Lahunta, De Vloo, Filipiddis, Fletcher, Hendson, Hertzler, Johnson, Lew, Michelson, Nakanishi, Ostling, Rade, Rade, Rade, Saker, Tu, Yamada, Yamada   +18 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

On viscosity, conduction and sound waves in the intracluster medium

, 2005
Recent X-ray and optical observations of the Perseus cluster indicate that the viscous and conductive dissipation of sound waves is the mechanism responsible for heating the intracluster medium and thus balancing radiative cooling of cluster cores.
A. C. Fabian, Bauer, Benson, Binney, Birzan, Blanton, Blanton, Braginskii, Böhringer, C. S. Reynolds, Carilli, Churazov, Churazov, Conselice, Crawford, Dunn, Edge, Fabian, Fabian, Fabian, Fabian, Fabian, Fujita, Fujita, G. B. Taylor, Heinz, Inogamov, Johnstone, Kaastra, Landau, Longcope, Lynds, McNamara, McNamara, Narayan, Navarro, Nulsen, Nulsen, Peres, Pringle, R. J. H. Dunn, Reynolds, Reynolds, Ruszkowski, Ruszkowski, Sanders, Spitzer, Stein, Taylor, Tozzi, Vogt, Voigt, Wilson, Zensus   +53 more
core   +4 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Treatment of necrotizing fasciitis using negative pressure wound therapy in a puppy [PDF]

, 2015
A two-month-old German shepherd dog was presented with anorexia, lethargy and left hind limb lameness associated with swelling of the thigh. Clinical findings combined with cytology led to the presumptive diagnosis of necrotizing fasciitis (NF ...
Abma, Eline, Bosmans, Tim, De Rooster, Hilde, Kitshoff, Adriaan, Stock, Emmelie, Vandenabeele, Sophie   +5 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Physiotherapy in small animal medicine [PDF]

, 2016
The benefits of physiotherapy have been extensively demonstrated in human medicine. Although physiotherapy has been performed in veterinary medicine for already several decades, it is only very recently that scientific research on this subject is ...
Samoy, Yves, Saunders, Jimmy, Van Ryssen, Bernadette   +2 more
core