Results 41 to 50 of about 33,128 (260)

Ten commandments to stifle academic freedom : a toolbox for autocrats

open access: yes
First published online on Verfassungblog: 02 May 2024Since 2010, the beginning of the populist takeover and the authoritarian transition, Hungary has gathered a lot of experience on how to dismantle academic freedom.
SZENTE, Zoltán
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Computed tomographic anatomy of the equine stifle joint

open access: yes, 2011
Objective-To provide a detailed computed tomography (CT) reference of the anatomically normal equine stifle joint. Sample-16 hind limbs from 8 equine cadavers; no horses had evidence of orthopedic disease of the stifle joints.
Erik H. J. Bergman   +13 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Canine stifle stability with CORA-based leveling osteotomy following cranial cruciate ligament transection and medial meniscal release, with and without stifle flexor loading: an ex-vivo biomechanical study

open access: yes, 2021
Introduction: This ex vivo study evaluated the effects of sequential cranial cruciate ligament transection (CCLx), medial meniscal release (MMR) and CORA-based leveling osteotomy (CBLO) on canine stifle stability compared to intact status, and assessed ...
Mazdarani, Parisa, Miles, James Edward
core  

Does cybersecurity risk stifle corporate innovation activities?

open access: yesInternational Review of Financial Analysis, 2023
Jimin Wang   +2 more
semanticscholar   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Stifle Injuries in the Canine

open access: yes, 1988
Stifle injuries are the most common cause for rear limb lameness in the adult dog. The recognition and treatment of these injuries is an important part of any small animal practice.
Radasch, Robert, Johnson, Jadid
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Distribution of lactate dehydrogenase in healthy and degenerative canine stifle joint cartilage [PDF]

open access: yes, 2007
In dogs, degenerative joint diseases (DJD) have been shown to be associated with increased lactate dehydrogenase (LDH) activity in the synovial fluid. The goal of this study was to examine healthy and degenerative stifle joints in order to clarify the ...
Schawalder, P   +6 more
core   +1 more source

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