Results 41 to 50 of about 5,631 (285)

Surgical Correction of Patellar Luxation in a Rabbit

open access: yesCase Reports in Veterinary Medicine, 2013
A two-and-a-half-year-old giant lop-eared rabbit, weighing 5.1 kg, presented with a one-month history of intermittent right hind limb lameness. The limb locked in extension during hopping.
J. Riggs, S. J. Langley-Hobbs
doaj   +1 more source

Finite Element Modelling Simulated Meniscus Translocation and Deformation during Locomotion of the Equine Stifle

open access: yesAnimals, 2019
We developed a finite element model (FEM) of the equine stifle joint to identify pressure peaks and simulate translocation and deformation of the menisci.
Pasquale Zellmann   +3 more
doaj   +1 more source

Biomechanical evaluation of two extracapsular techniques for cranial cruciate ligament reconstruction in cadaver dogs

open access: yesSemina: Ciências Agrárias, 2016
Cranial cruciate ligament rupture (CCLR) is one of the most important orthopedic conditions in dogs, leading to joint instability, pain, osteoarthritis and eventually to meniscal injuries.
Sam Golgy Shoyama Oda   +5 more
doaj   +1 more source

Biomechanical effects of cranial closing wedge osteotomy on joint stability in normal canine stifles: an ex vivo study

open access: yesBMC Veterinary Research
Background Cranial closing wedge osteotomy (CCWO) is a functional stabilisation technique for cranial cruciate ligament (CrCL) ruptures. This biomechanical study aimed to evaluate the influence of CCWO on the stability of the stifle joint.
Masakazu Shimada   +6 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Effect of anesthetizing individual compartments of the stifle joint in horses with experimentally induced stifle joint lameness

open access: yesAmerican Journal of Veterinary Research, 2014
Abstract Objective—To evaluate the effects of sequential anesthesia of the individual compartments of the equine stifle joint on lameness induced by intra-articular deposition of interleukin (IL)-1β. Animals—6 horses. Procedures—For each horse, baseline hind limb lameness was first evaluated.
Ferenc, Tóth   +3 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Radiographic risk factors for contralateral rupture in dogs with unilateral cranial cruciate ligament rupture. [PDF]

open access: yesPLoS ONE, 2014
Complete cranial cruciate ligament rupture (CR) is a common cause of pelvic limb lameness in dogs. Dogs with unilateral CR often develop contralateral CR over time.
Connie Chuang   +7 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

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