Results 121 to 130 of about 263,271 (408)

Laxatives do not improve symptoms of opioid-induced constipation: results of a patient survey [PDF]

, 2017
Introduction: Laxatives are commonly used to treat opioid-induced constipation, the commonest and most bothersome complication of opioids. However, laxatives have a non-specific action and do not target underlying mechanisms of opioid-induced ...
Emmanuel, Anton, Johnson, Martin, McSkimming, Paula   +2 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Differentiation of Therapeutic and Illicit Drug Use via Metabolite Profiling

Metabolites
Objectives: The therapeutic use of controlled substances, particularly opioids, stimulants, and benzodiazepines, has significantly increased in recent decades.
Stanila Stoeva-Grigorova, Nadezhda Hvarchanova, Silvia Gancheva, Miroslav Eftimov, Kaloyan D. Georgiev, Maya Radeva-Ilieva   +5 more
doaj   +1 more source

Review on analytical methods for quantification of ADHD drugs in human biological samples

Reviews in Analytical Chemistry, 2020
Attention deficit hyperactivity disorder (ADHD) is a common neuro-developmental disorder. The symptoms of ADHD include difficulty in attention, memory and impulse control.
Sundari J., Amuthalakshmi S., Nalini C.N.   +2 more
doaj   +1 more source

Coping Skills for Students with ADHD [PDF]

, 2011
Students diagnosed with Attention Deficit/Hyperactivity Disorder (ADHD) are often seen as problem students with little hope for academic success. It is common for these students to be medicated with a daily dosage of stimulants to help them function ...
Brighton, David
core  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Satisfacción con la atención de enfermería en los consumidores de drogas: evolución de una escala [PDF]

, 2017
Objectives: To identify the degree of satisfaction with nursing care, the significant variables and contribute to the evolution of the scale.Methods: Descriptive, correlational, cross study, with 180 drug users.
Amendoeira, José, Ribeiro, Ana Leonor, Seabra, Paulo Rosário Carvalho, Sá, Luis Octávio   +3 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Clinical and Prognostic Findings in Psychotropic Substance Poisoning: A Cross-sectional Study [PDF]

Pharmaceutical and Biomedical Research
Background: Psychotropic substance poisoning is a growing public health concern.  Objectives: This study aimed to investigate patients with psychedelic poisoning and evaluate the frequency of clinical, preclinical, and prognostic findings.
Hanieh Hatampour, Hamid Reza Jamshidi, Komeil Aghazadeh-Habashi, Sareh Rafatmagham, Farhad Farnaghi, Hamidreza Ghasemirad, Mehrnoush Giahi Yazdi, Mohsen Jabari, Khashayar Moravej, Hamid Owliaey   +9 more
doaj  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source