Results 221 to 230 of about 706,846 (235)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Skin Regeneration in Diabetic Rats Using Gold Nanoparticles-Bioactive Glass Oil-in-Water Cream. [PDF]

Materials (Basel)
Mârza SM, Purdoiu RC, Potârniche AV, Tătaru M, Peştean C, Nagy AL, Tăbăran AF, Gog-Bogdan S, Papuc I, Moldovan M, Tóth ZR, Baia L, Magyari K.   +12 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Evaluation of Imoviral^® effects on early immune response in <i>Sparus aurata</i> challenged with <i>Vibrio anguillarum</i>. [PDF]

Front Immunol
Natale S, Savoca S, Capparucci F, Capillo G, Mancuso M, Bragason BT, Riolo K, Giannetto A, Marino F, Iaria C.   +9 more
europepmc   +1 more source

Subcutaneous drug delivery of high concentration antibody products - part 2: formulation, device options, and clinical bridging strategies for patient-centric commercial presentations. [PDF]

MAbs
Ghosh I, Deodhar S, Gutka H, Sridharan S, Bindra D.   +4 more
europepmc   +1 more source

Digital motivation for cervical cancer screening: A quasi-experimental trial of the SeDAR Video among middle adulthood Malaysian women. [PDF]

PLoS One
Romli R, Mohammed Nawi A, Abd Rahman R, Mohamad EMW, Chew KT, Mohd Hashim S.   +5 more
europepmc   +1 more source

Photosynthetic Microorganisms in Plant Growth Promotion and Stress Response: Proposed Organisms with In Silico Validation. [PDF]

Plants (Basel)
Asvesta OD, Kotsadam E, Mouchtaropoulou E, Argiriou A.   +3 more
europepmc   +1 more source

Study on the therapeutic effect of eggshell membrane on osteoarthritis in rats. [PDF]

PLoS One
Pan M, Shen Y, Wu J, Liu C, Zhu M, Zhou Z.   +5 more
europepmc   +1 more source