Results 101 to 110 of about 2,008,819 (319)

Deep Brain Stimulation for Disabling “Outflow” Tremors

, 2020
“Outflow” tremors, sometimes referred to in the literature by a variety of terms (outflow, rubral, midbrain, Holmes), are frequently associated with significant disability and are notoriously unresponsive or only partially responsive to medical treatment.
Shpiner, Danielle S, Luca, Corneliu C, Khemani, Pravin, Okun, Michael S, Bette, Sagari, Chitnis, Shilpa   +5 more
core   +1 more source

Voluntary activation of human knee extensors measured using transcranial magnetic stimulation [PDF]

, 2009
The aim of this study was to determine the applicability and reliability of a transcranial magnetic stimulation twitch interpolation technique for measuring voluntary activation of a lower limb muscle group.
Ross, Emma, E. Z. Ross, Goodall, Stuart, Goodall, S., Romer, Lee, Romer, L., Romer, LM, Ross, EZ, L. M. Romer, Goodall, S, S. Goodall   +10 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Consensus: Can transcranial direct current stimulation and transcranial magnetic stimulation enhance motor learning and memory formation?

Noninvasive brain stimulation has developed as a promising tool for cognitive neuroscientists. Transcranial magnetic (TMS) and direct current (tDCS) stimulation allow researchers to purposefully enhance or decrease excitability in focal areas of the ...
Born, Jan, Classen, Joseph, Floel, Agnes, Wassermann, Eric M, Cohen, Leonardo G, Gerloff, Christian, Robertson, Edwin M, Pascual-Leone, Alvaro, Reis, Janine, Hummel, Friedhelm, Paulus, Walter, Siebner, Hartwig R, Celnik, Pablo A, Krakauer, John W, Rothwell, John, Marshall, Lisa, Ziemann, Ulf   +16 more
core   +1 more source

The Influence of Deep Brain Stimulation Intensity and Duration on Symptoms Evolution in an OFF Stimulation Dystonia Study

, 2013
Background: Deep brain stimulation (DBS) of the internal globus pallidus (GPi) is an established therapy for primary generalized dystonia. However, the evolution of dystonia symptoms after DBS discontinuation after years of therapy has only rarely been ...
Ruge, Diane, Limousin, Patricia, Gonzalez, Victoria, Vasques, Xavier, Cif, Laura, Hariz, Marwan I.,, Coubes, Philippe, Rothwell, John   +7 more
core   +1 more source

The “fracture-controlled reserves” based stimulation technology for unconventional oil and gas reservoirs

Petroleum Exploration and Development, 2018
To solve the problems facing the economic development of unconventional oil and gas, a new concept and corresponding technology system of reservoir stimulation based on “fracture-controlled reserves” are put forward.
Qun LEI, Lifeng YANG, Yaoyao DUAN, Dingwei WENG, Xin WANG, Baoshan GUAN, Zhen WANG, Ying GUO   +7 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Trigeminal Nerve Stimulation Does Not Acutely Affect Cortical Excitability in Healthy Subjects

, 2014
BACKGROUND: Trigeminal nerve stimulation (TNS) has recently emerged as a new therapeutic option for patients with drug-resistant epilepsy but its potential mechanisms of action are not known.
Isberg, Mattias,, Flink, Roland,, Amandusson, Åsa,, Axelson, Hans W,   +3 more
core   +1 more source

Modulation of interhemispheric inhibition and motor learning by different intensities of bilateral transcranial direct current stimulation in healthy adults

Scientific Reports
Interhemispheric inhibition (IHI) plays a crucial role in performing unilateral hand movements. Transcranial direct current stimulation (tDCS) has been shown to modulate IHI and enhance motor learning, but the most effective stimulation intensity remains
Thatchaya Prathum, Julien Dauguet, Irin Apiworajirawit, Benchaporn Aneksan, Siriwan Hoisan, Arruck Tragangoon, Vorasith Siripornpanich, Wanalee Klomjai   +7 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source