Results 121 to 130 of about 2,008,819 (319)

Corticomotor Responses to Experimental, Acute, and Chronic Lower Limb Pain: A Systematic Review and Meta‐Analysis

Brain and Behavior
Background: Corticomotor adaptations are believed to contribute to persistent pain. However, prior reviews have lacked sufficient data to adequately explore these adaptations in lower limb pain.
Simon J. Summers, Jawwad Imam, Edward Gray, Ariane Suhood, Ebonie Rio, Cherylea J. Browne, Nadia Moukhaiber, Rocco Cavaleri   +7 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Spatial-temproal variability of snow cover in arid regions of Central Asia

Shui kexue jinzhan, 2018
Remote sensing of snow information in arid regions of Central Asia can provide data support for the allocation and utilization of water resources in transboundary rivers and play an important role in the ecological security of major national strategies ...
CHEN Wenqian, DING Jianli, MA Yonggang, ZHANG Zhe, ZHOU Jie   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Transcutaneous vagus nerve stimulation: retrospective assessment of cardiac safety in a pilot study.

, 2012
Background: Vagus nerve stimulation has been successfully used as a treatment strategy for epilepsy and affective disorders for years. Transcutaneous vagus nerve stimulation (tVNS) is a new non-invasive method to stimulate the vagus nerve, which has been
Berthold Langguth, Michael Landgrebe, Prasser, Sarah Julia, Martin Schecklmann, Michael eLandgrebe, Resch, Markus, Markus eResch, Martin eSchecklmann, Florian eGeisreiter, Goeran eHajak, Landgrebe, Michael, Markus Resch, Hajak, Göran, Langguth, Berthold, Timm B Poeppl, Berthold eLangguth, Sarah Julia Prasser, Schecklmann, Martin, Kreuzer, Peter M., Oliver eHusser, Timm B. Poeppl, Husser, Oliver, Peter M. Kreuzer, Oliver Husser, Geisreiter, Florian, Peter Michael Kreuzer, Goeran Hajak, Poeppl, Timm B., Florian Geisreiter   +28 more
core   +1 more source

External physical and biochemical stimulation to enhance skeletal muscle bioengineering [PDF]

, 2015
Cell based muscle tissue engineering carries the potential to revert the functional loss of muscle tissue caused by disease and trauma. Although muscle tissue can be bioengineered using various precursor cells, major limitations still remain.; In the ...
Handschin, Christoph, Eberli, Daniel, Mortezavi, Ashkan, Plock, Jan, Plock, Jan; https://orcid.org/, Eberli, Daniel; https://orcid.org/   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dissociating linguistic processes in the left inferior frontal cortex with transcranial magnetic stimulation

, 2005
Is the left inferior frontal cortex (LIFC) a single functional region, or can it be subdivided into distinct areas that contribute differently to word processing?
Nobre, AC, Devlin, JT, Gough, PM
core   +1 more source

A Pilot Study of Rhythmic Breathing Yoga Combined with TMS

Brain Stimulation, 2021
Sandeep Vaishnavi, MD, PhD, Caroll Brammer, MBA   +1 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source