Results 141 to 150 of about 2,008,819 (319)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Sustainable Enhanced Oil Recovery Using Polyfraction Nanoemulsions with Alternating Injection Strategies

Applied Sciences
Enhanced oil recovery (EOR) can significantly contribute to sustainable energy by improving oil recovery efficiency, integrating renewable technologies, and reducing the environmental impact of extraction.
Klaudia Wilk-Zajdel, Piotr Kasza, Marek Czupski   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Goal-orientated Functional Rehabilitation using Electrical Stimulation and Iterative Learning Control for Motor Recovery in the Upper Extremity Post-Stroke.

, 2013
There is increasing evidence that electrical stimulation (ES) combined with task specific training is effective in the recovery of upper extremity dysfunction following stroke.
Freeman, Christopher T., Hallewell, Emma, Hallewell, E., Meadmore, K.L ., Hughes, A. M., Exell, T., Hughes, Ann Marie, Hughes, Ann-Marie, Burridge, J.H., Kutlu, Mustafa, Freeman, C., Meadmore, K. L., Kutlu, M., Hughes, A-M., Meadmore, Katie L., Burridge, J., Burridge, J. H., Excell, T., Freeman, C.T., Meadmore, K.   +19 more
core  

Controversy: Noninvasive and invasive cortical stimulation show efficacy in treating stroke patients

Stroke is the leading cause of disability in the adult population of western industrialized countries. Despite significant improvements of acute stroke care, two thirds of stroke survivors have to cope with persisting neurologic deficits.
Pascual-Leone, Alvero, Buetefisch, Cathrin M, Hummel, Friedhelm C, Celnik, Pablo, Fregni, Felipe, Cohen, Leonardo G, Gerloff, Christian, Rothwell, John, Byblow, Winston D   +8 more
core   +1 more source

Neck atonia with a focal stimulation-induced seizure arising from the SMA: pathophysiological considerations.

, 2012
A 28-year-old patient with pharmacoresistant non-lesional right frontal epilepsy underwent extra-operative intracranial EEG recordings and electrical cortical stimulation (ECS) to map eloquent cortex.
Nachev, P, McEvoy, Andrew W., Wehner, T, Kovac, S, Diehl, B, Duncan, JS, Duncan, John S., Rodionov, Roman, Toms, Nathan, Toms, N, Diehl, Beate, Kovac, Stjepana, Wehner, Tim, Scott, Catherine, Nachev, Parashkev, Scott, C, Rodionov, R, McEvoy, AW   +17 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Human applications of transcranial temporal interference stimulation: A systematic review

This is the final published version of the article, made available under the CC BY-NC 4.0 license. It was published by Elsevier BV in Brain Stimulation.
Schweizer, Tom A., Demchenko, Ilya, Boyden, Edward S., Bhat, Venkat, Chegini, Sina, Graham, Simon J., Rueda, Alice, Gholamali Nezhad, Fatemeh, Krishnan, Sridhar, Meltzer, Jed A., Lozano, Andres M., Tailor, Ishaan, Violante, Ines R., Kever, Anne, Yu, Haochen, Datta, Abhishek, Rampersad, Sumientra, Chen, Robert   +17 more
core   +1 more source

Accelerated recovery using magnesium ibogaine: characterizing the subjective experience of its rapid healing from neuropsychiatric disorders

npj Mental Health Research
Magnesium-ibogaine, a formulation combining ibogaine with pre- and post-treatment magnesium, was recently found to yield rapid clinical improvements in U.S. Special Operations veterans with TBI and PTSD.
Clayton Olash, Derrick Matthew Buchanan, Randi Brown, Afik Faerman, Kirsten Cherian, George Lin, David Spiegel, James J. Gross, Nolan Williams   +8 more
doaj   +1 more source