Results 161 to 170 of about 3,130,394 (254)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Restoring Theta-Gamma coupling in Alzheimer's disease: Toward network-based neuromodulation. [PDF]

Neurotherapeutics
Jiang S.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Acute Effect of Transcutaneous Auricular Vagus Nerve Stimulation in Two Different Locations on Blood Pressure and Cardiac Autonomic Modulation in Healthy and Hypertensive Individuals: Pilot Study of a Randomized Crossover Clinical Trial. [PDF]

Physiother Res Int
Leite Souza PH, Ferrari Corrêa JC, Venâncio BP, Buzá LS, Oliveira da Silva G, Fregni F, Consolim-Colombo FM, Ritti Dias RM, Corrêa FI.   +8 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Miniaturized optically generated Bessel beam ultrasound for volumetric transcranial brain stimulation. [PDF]

Sci Adv
Li Y, Chen G, Oliveira TR, Todd N, Zhang YZ, Marar C, Zheng N, Lan L, McDannold N, Cheng JX, Yang C.   +10 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Progress in non-invasive neuromodulation based on consciousness-related neural circuits: a narrative review. [PDF]

Front Neurol
Wang Y, Zhai Y, Zheng Z, Wang N, Chai X, Niu H, Jia Y, Zhu S, Shang Y, Wan K, Cao T, He Q, Zhang T, Qiu H, Yang Y.   +14 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Synaptic Facilitation Enhances the Reliability and Precision of High-Frequency Neurotransmission. [PDF]

J Neurosci
Bernal-Correa AM, Dagostin A, von Gersdorff H, Kushmerick C.   +3 more
europepmc   +1 more source