Results 51 to 60 of about 1,494,443 (249)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Neuroplasticity associated with tactile language communication in a deaf-blind subject

Frontiers in Human Neuroscience, 2010
A longstanding debate in cognitive neuroscience pertains to the innate nature of language development and the underlying factors that determine this faculty. We explored the neural correlates associated with language processing in a unique individual who
Souzana Obretenova, Mark A Halko, Ela B Plow, Alvaro Pascual-Leone, Lotfi B Merabet   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Causal connectivity maps derived from single-pulse interleaved TMS/fMRI

Scientific Reports
Understanding causal interactions between cortical and subcortical brain regions is critical for mapping human functional connectivity. While non-invasive methods such as fMRI and diffusion imaging have provided valuable insights into brain connectivity,
Lison Bossus, Jess Dickson, Camille Blaine, Hasti Khalilkhani, Ahsan Khan, Desmond J. Oathes   +5 more
doaj   +1 more source

Stimulant Medications

Journal of the American Academy of Child & Adolescent Psychiatry, 1999
To review the short- and long-term safety and efficacy of stimulants for the treatment of children with attention-deficit/hyperactivity disorder (ADHD).A Medline search was conducted for both randomized controlled trials and reviews to determine the efficacy and safety of stimulant drugs for treating children with ADHD.
L L, Greenhill, J M, Halperin, H, Abikoff   +2 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Neuronavigated 20hz theta burst TMS of the right orbitofrontal cortex in the treatment of obsessive compulsive disorder

Brain Stimulation, 2023
William Stubbeman, Julianne Converse, Melodi Gencosmanoglu, Daisy Morales Ortega, Jordyn Morris, Raya Khairkhah   +5 more
doaj   +1 more source

A systematic review and meta-analysis of the impact of transcranial direct current stimulation on cognitive function in older adults with cognitive impairments: the influence of dosage parameters

Alzheimer’s Research & Therapy
Introduction Numerous studies have demonstrated the effects of transcranial direct current stimulation (tDCS) on cognitive function in the older people. This study further explores the impact of tDCS and its dosage parameters on cognitive enhancement in ...
Thatchaya Prathum, Thanwarat Chantanachai, Oranich Vimolratana, Chotica Laksanaphuk, Irin Apiworajirawit, Benchaporn Aneksan, Kanthika Latthirun, Cheng-Ta Yang, Wanalee Klomjai   +8 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Technological progress and prospects of reservoir stimulation

Petroleum Exploration and Development, 2019
Through reviewing the development history of reservoir hydraulic fracturing technology, this paper demonstrated the latest research progress at home and abroad and summarized six technical gaps between China and the world, that is fracture propagation ...
Qun LEI, Baoshan GUAN, Bo CAI, Xin WANG, Yun XU, Zheng TONG, Haiyan WANG, Haifeng FU, Ze LIU, Zhen WANG   +9 more
doaj   +1 more source