Results 71 to 80 of about 192,511 (266)

Stimuli-responsive polymers at the interface with biology

Biomacromolecules
Inspired by the responsiveness of natural systems to their surrounding environments, researchers have sought to understand these biological processes and to develop functional stimuli-responsive polymeric systems for a wide range of applications such as drug delivery, imaging, and regenerative medicine. Both synthetic polymers and biopolymers have been
Nathan R. B. Boase, Elizabeth R. Gillies, Rubayn Goh, Roxanne E. Kieltyka, John B. Matson, Fenghua Meng, Amitav Sanyal, Ondřej Sedláček   +7 more
openaire   +5 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Biomedical applications of stimuli‐responsive nanomaterials

MedComm
Nanomaterials have aroused great interests in drug delivery due to their nanoscale structure, facile modifiability, and multifunctional physicochemical properties.
Xiaojie Chen, Di Wu, Zhong Chen
doaj   +1 more source

A review of smart polymeric materials: Recent developments and prospects for medicine applications

Hybrid Advances
To adapt to the changes in nature, living systems adjust their structure and function according to the environmental conditions. Scientists are inspired by nature and try to create materials that can change their behavior depending on the situation, just
Arash Fattah-alhosseini, Razieh Chaharmahali, Sajad Alizad, Mosab Kaseem, Burak Dikici   +4 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Progress in Preparation and Application of Stimulus-response Zein-based Nanoparticles

Shipin gongye ke-ji
Zein is a primary by-product of corn starch processing, which is inexpensive and easily obtainable. Based on its unique self-assembly properties, zein could be constructed into nanoparticles through various methods, enabling the loading and delivery of ...
Wei WANG, Yan CUI, Mingzhu ZHENG, Meihong LIU, Huimin LIU   +4 more
doaj   +1 more source

Stimuli Responsive Polymeric Systems for Cancer Therapy

Pharmaceutics, 2018
Nanoscale polymers systems have dominated the revolution of drug delivery advancement. Their potential in the fight against cancer is unrivalled with other technologies.
Ali Alsuraifi, Anthony Curtis, Dimitrios A. Lamprou, Clare Hoskins   +3 more
doaj   +1 more source