Results 41 to 50 of about 6,307,267 (312)

Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment

Pharmaceutics, 2019
Despite the fact that nanocarriers as drug delivery systems overcome the limitation of chemotherapy, the leakage of encapsulated drugs during the delivery process to the target site can still cause toxic effects to healthy cells in other tissues and ...
Ngoc Thuy Trang Le, Thi Nhu Quynh Nguyen, Van Du Cao, Duc Thuan Hoang, Van Cuong Ngo, Thai Thanh Hoang Thi   +5 more
doaj   +1 more source

Emerging applications of stimuli-responsive polymer materials

Nature Materials, 2010
Responsive polymer materials can adapt to surrounding environments, regulate transport of ions and molecules, change wettability and adhesion of different species on external stimuli, or convert chemical and biochemical signals into optical, electrical, thermal and mechanical signals, and vice versa.
Stuart, M.A.C., Huck, W.T.S., Genzer, J., Muller, M., Muller, M., Ober, C., Stamm, M., Sukhorukov, G.B., Szleifer, I., Tsukruk, V.V., Urban, M., Winnik, F., Zauscher, S., Luzinov, I., Minko, S.   +14 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Anomalous Magnetorheological Response for Carrageenan Magnetic Hydrogels Prepared by Natural Cooling

Gels, 2023
The effect of the cooling rate on magnetorheological response was investigated for magnetic hydrogels consisting of carrageenan and carbonyl iron particles with a concentration of 50 wt.%.
Masahiro Kaneko, Mika Kawai, Tetsu Mitsumata   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Direct Ink Writing of a Light‐Responsive Underwater Liquid Crystal Actuator with Atypical Temperature‐Dependent Shape Changes [PDF]

, 2020
In recent years, light‐responsive liquid crystal (LC) polymers have been studied as promising materials for the fabrication of untethered soft actuators. The underwater behavior of these advanced materials has, however, been rarely investigated.
Marc del Pozo, Pilz Da Cunha, Marina, Liu, Li, del Pozo Puig, Marc; id_orcid, Broer, Dirk J.; id_orcid, del Pozo Puig, Marc, Schenning, Albert P.H.J., Schenning, Albert P.H.J.; id_orcid, Li Liu, Broer, Dirk J., Dirk J. Broer, Albert P. H. J. Schenning, Marina Pilz da Cunha   +12 more
core   +3 more sources

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Unlocking the potential of stimuli-responsive injectable hydrogels for bone healing applications

Frontiers in Biomaterials Science
Stimuli-responsive, or “smart”, injectable hydrogels respond to real-time stimuli through physical or chemical changes. This allows hydrogels to be dynamic within their environment in the presence of internal or external stimuli.
Abdulla Al Mamun, Yasmeen Shamiya, Anwarul Hasan, Anwarul Hasan, Anwarul Hasan, Arghya Paul, Arghya Paul   +6 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source