Results 61 to 70 of about 6,307,267 (312)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Recoverable and Sensitive Pressure-Induced Mechanochromic Photoluminescence of a Au-P Complex

Molecules
A binuclear Au-P complex [Au2(2-bdppmapy)2](PF6)2 (1) was synthesised by the reaction of 2-bdppmapy (N,N′-bis-(diphenylphosphanylmethyl-2-aminopyridine) with AuCN and [Cu(MeCN)4]PF6.
Ningwen Yang, Yijia Chang, Jiangyue Wang, David James Young, Hong-Xi Li, Yuxin Lu, Zhi-Gang Ren   +6 more
doaj   +1 more source

Responsive polymer photonics [PDF]

, 2014
Stimulus-responsive materials: This thesis describes the development of stimulus-responsive polymeric materials based on liquid crystalline polymers and hydrogels. Novel responsive molecular building blocks were designed and synthesised. Specific monomer
Stumpel, JE Jelle, Stumpel, J.E., Jelle E. Stumpel   +2 more
core   +3 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Biomedical applications of stimuli-responsive “smart” interpenetrating polymer network hydrogels

Materials Today Bio
In recent years, owing to the ongoing advancements in polymer materials, hydrogels have found increasing applications in the biomedical domain, notably in the realm of stimuli-responsive ''smart'' hydrogels.
Jiuping Wu, Wu Xue, Zhihe Yun, Qinyi Liu, Xinzhi Sun   +4 more
doaj   +1 more source

Stimuli-responsive microgel-based etalons for optical sensing

, 2015
Responsive polymer-based materials (or smart materials) have found numerous uses over the years due to their ease of synthesis and various responsivities/functionalities.
Li, Xue, Gao, Yongfeng, Serpe, Michael J.   +2 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Stimuli-Responsive Polymers as Adjuvants and Carriers for Antigen Delivery

, 2013
Stimuli responsive polymers are gaining importance in immunology not only as carriers for delivering antigens to target tissues but also as immunologically inert adjuvants.
Shakya, Akhilesh Kumar,, Nandakumar, Kutty Selva,, Kutty Selva Nandakumar, Akhilesh Kumar Shakya   +3 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source