Results 51 to 60 of about 585,821 (290)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Construction of biocomputing systems based on switchable bioelectrocatalysis and stimulus-responsive film electrodes

Sensors and Actuators Reports, 2021
The construction of biocomputing platforms, particularly based on multiple stimulus-responsive film electrodes and switchable bioelectrocatalysis, is briefly overviewed.
Wenjing Lian, Ruiqi Xiao, Jiaxuan Li, Huiqin Yao, Hongyun Liu   +4 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat
Liposomes have emerged as the most clinically successful nanocarriers with good biocompatibility, low immunogenicity, and facile modification potential.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
doaj   +1 more source

Stimulus-Responsive Membranes: A Mini Review on Principles, Preparation Methods, and Emerging Applications

Separations
Membrane separation technology can be operated in moderate conditions with low energy consumption and has been widely explored and increasingly applied in the water treatment, food, chemical, and pharmaceutical industries.
Yixin Wu, Ziyu Wang, Jian Zhou, Qilin Gu, Zhaoxiang Zhong   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Stimulus-Responsive Polymers for Bioseparation

CHIMIA, 2001
Affinity precipitation uses reversibly water-soluble affinity macroligands, i.e. stimulus-responsive polymers bearing one or several affinity ligands, to first capture and then co-precipitate a target molecule.
Ruth Freitag, Matteo Costioli, Frédéric Garret-Flaudy   +2 more
doaj  

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Supramolecular vesicles for stimulus-responsive drug delivery

, 2018
Developing smart controlled‐release systems for cancer therapy is highly desired in biomedicine. In order to improve therapeutic efficacy and lower undesired side effects, the construction of stimulus‐responsive nanocarriers is a favorable solution ...
Xing, Pengyao, Pengyao Xing, Yanli Zhao, Zhao, Yanli   +3 more
core   +1 more source