Results 71 to 80 of about 11,420 (260)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Resolução de problemas aritméticos: efeito de relações de equivalência entre três diferentes formas de apresentação dos problemas Arithmetic problem-solving: effect of equivalence relations between three different forms of presenting problems

Psicologia: Reflexão e Crítica, 2006
O paradigma da equivalência de estímulos tem sido usado para o desenvolvimento de diversos procedimentos aplicáveis ao ensino de leitura, escrita e aritmética.
Verônica Bender Haydu, Lucita Portela da Costa, Elsa Maria Mendes Pessoa Pullin   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

FORMACIÓN DE CLASES EQUIVALENTES A TRAVÉS DE REGLAS VERBALES Y FORMATO MANUAL [PDF]

Acta Colombiana de Psicología, 2008
Equivalent class formation through verbal rules was analyzed. A matching-to-sample procedure for training and probing of conditional discriminations in a “paper and pencil” format was used.
Tovar y Romo, Ángel, Torres Chávez, Álvaro   +1 more
doaj  

Class size effects on the maintenance of equivalence relations with an intra-group design

Interação em Psicologia, 2009
Like the formation of equivalence classes, their maintenance is affected by diverse experimental variables. The present study aimed to analyze the effect of class size on the formation and maintenance of equivalent stimuli classes with an intra-group ...
Verônica Bender Haydu, Leila Cristina Ferreira Omote, Priscila Vicente, Natalia Maria Aggio, Juliana Barboza Caetano de Paula   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Conditional associative learning examined in a paralyzed patient with amyotrophic lateral sclerosis using brain-computer interface technology

Behavioral and Brain Functions, 2008
Background Brain-computer interface methodology based on self-regulation of slow-cortical potentials (SCPs) of the EEG (electroencephalogram) was used to assess conditional associative learning in one severely paralyzed, late-stage ALS patient.
Birbaumer N, Neumann N, Kübler A, Ghanayim N, Iversen IH, Kaiser J   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Relações de equivalência após treino com pareamento consistente de estímulos sob controle contextual

Psicologia: Teoria e Pesquisa
Alguns estudos têm produzido relações condicionais que se mostraram também equivalentes, através do treino com pareamento consistente de estímulos. O presente estudo buscou verificar se essas relações podem ocorrer também sob controle contextual.
Grauben José Alves de Assis, Marcelo Quintino Galvão Baptista, Olívia Misae Kato, Keila Regina Alves   +3 more
doaj   +1 more source