Results 81 to 90 of about 64,868 (308)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Ensinando subtração para pessoas com deficiência mental com base em relações de equivalência de estímulos

open access: yesPsicologia: Teoria e Pesquisa
Foi avaliado um procedimento para o ensino de subtração a indivíduos deficientes mentais, por meio de relações ambientadas em tarefas de MTS. O primeiro passo consistiu nos testes das relações da classe ABC (relações quantitativas de 1 a 9) e FGH ...
Priscila Mara de Araújo   +1 more
doaj   +1 more source

The return of fiscal policy and the euro area fiscal rule [PDF]

open access: yes, 2020
The text describes the theoretical developments of the assignment rules regarding fiscal and monetary policies and the respective roles in macroeconomics stabilisation.
Constâncio, Vítor
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Conceito de número: uma contribuição da análise comportamental da cognição

open access: yesPsicologia: Teoria e Pesquisa
Fundamenta-se o presente estudo na análise comportamental da cognição, cujas formulações permitem compreender o conceito de número como uma rede de relações entre estímulos e/ou entre estímulos e respostas.
Paulo Sérgio Teixeira do Prado   +1 more
doaj   +1 more source

QUANTITATIVE AND METHODOLOGICAL ASPECTS OF STIMULUS EQUIVALENCE [PDF]

open access: yesJournal of the Experimental Analysis of Behavior, 1991
The number of different ways of linking stimuli in the training phase of a conditional discrimination procedure designed to teach equivalence relations has hitherto been underestimated. An algorithm from graph theory that produces the correct number of such different ways is given. The establishment of equivalence relations requires transitive stimulus
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Rearmament to the rescue? New estimates of the impact of ‘Keynesian’ policies in 1930s’ Britain [PDF]

open access: yes, 2012
We report estimates of the fiscal multiplier for interwar Britain based on quarterly data, time-series econometrics, and ‘defense news’. We find that the government expenditure multiplier was in the range 0.3 to 0.8, much lower than previous estimates ...
Crafts, N. F. R., Mills, Terence C.
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

FORMACIÓN DE CLASES EQUIVALENTES A TRAVÉS DE REGLAS VERBALES Y FORMATO MANUAL [PDF]

open access: yesActa Colombiana de Psicología, 2008
Equivalent class formation through verbal rules was analyzed. A matching-to-sample procedure for training and probing of conditional discriminations in a “paper and pencil” format was used.
Tovar y Romo, Ángel   +1 more
doaj  

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