Results 121 to 130 of about 70,402 (307)

Binding of bacterial secondary messenger molecule c di-GMP is a STING operation

, 2013
Initial skirmishes between the host and pathogen result in spillage of the contents of the bacterial cell. Amongst the spillage, the secondary messenger molecule, cyclic dimeric guanosine monophosphate (c di-GMP), was recently shown to be bound by ...
Ouyang, Songying, Liu, Zhi-jie, Shaw, Neil, Liu, ZJ (reprint author), Chinese Acad Sci, Inst Psychol, Natl Lab Biomacromol, Beijing 100101, Peoples R China.   +3 more
core   +1 more source

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson’s disease

Neural Regeneration Research
Interferon regulatory factor 7 plays a crucial role in the innate immune response. However, whether interferon regulatory factor 7-mediated signaling contributes to Parkinson’s disease remains unknown.
Shengyang Zhou, Ting Li, Wei Zhang, Jian Wu, Hui Hong, Wei Quan, Xinyu Qiao, Chun Cui, Chenmeng Qiao, Weijiang Zhao, Yanqin Shen   +10 more
doaj   +1 more source

Reservoir‐Driven Neuromorphic Computing Based on Composite Rare‐Earth/Transition Metal Oxide Memristor

Advanced Functional Materials, EarlyView.
A defect‐engineered Ag/Gd2O3:Nb2O5/Pt rare earth composite oxide memristor enables stable multilevel reservoir states through pulse driven conductance modulation. Experimentally measured device responses are incorporated into a device aware reservoir computing framework for CIFAR‐100 image classification, highlighting the potential of rare earth ...
Hammad Ghazanfar, Haider Abbas, Muhammad Rabeel, Honggyun Kim, Ghulam Dastgeer, Muhammad Nasim, Furqan Zahoor, Yawar Abbas, Waqas Ahmad, Deok‐kee Kim   +9 more
wiley   +1 more source

Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in mice [PDF]

Stimulator of interferon genes (STING) is activated after detection of cytoplasmic dsDNA by cGAS (cyclic GMP-AMP synthase) as part of the innate immunity defence against viral pathogens. STING binds TANK-binding kinase 1 (TBK1).
Falkenburger, Björn H, Bernhardt, Nadine, Rösen-Wolff, Angela, Luksch, Hella, Szego, Eva M., Malz, Laura   +5 more
core   +1 more source

Melanin's Role in Balancing Mechanical Strength and Reproductive Output in Environmentally Stressed Fungal Spores

Advanced Functional Materials, EarlyView.
Melanin content directly controls fungal spore mechanical properties, with pigmented spores achieving rupture forces two orders of magnitude higher than hyaline spores. Environmental stress drives this quantity‐quality tradeoff; stressed species invest energy in melanin‐reinforced, mechanically superior thick‐walled, super‐hydrophobic spores, while ...
Atul Agrawal, Steven E. Naleway
wiley   +1 more source

Graded Metallopolymer Structures with Shape‐Memory Abilities via DLP‐Based 3D‐Printing

Advanced Functional Materials, EarlyView.
This study presents the digital light processing (DLP) based 3D printing of graded metallopolymers featuring shape‐memory abilities. The permanent shape can be recovered in two distinct steps with excellent rates. The obtained graded prints range from simple rod‐like structures to complex hollow materials.
Michael Klein, Michael F. Agyemang, Michael Schmitt, Jürgen Popp, Martin D. Hager, Stefan Zechel, Ulrich S. Schubert   +6 more
wiley   +1 more source

Flawed sting operation singles out open access journals

, 2013
In a sting operation, John Bohannon, a correspondent of Science, claims to have exposed dodgy open access journals. His argument seems to be that, because of their business model, some journals are biased towards accepting scientific articles, regardless
Eve, Martin Paul
core  

Forward‐Biased Perovskite Photodiodes for In‐Sensor Optical Change Sensing

Advanced Functional Materials, EarlyView.
A forward‐biased perovskite photodiode is introduced as an in‐sensor analog preprocessing unit that uses current balancing between photocurrent and injection current to generate optical changes relative to programmable optical reference levels. The device directly converts reference‐relative optical changes into bipolar current signals, enabling sensor‐
Eungseon Yeon, Je‐Jun Lee, Somin Yun, Sangin Hahn, Chanhyeok Kim, Jinsoo Park, Jung Pyo Hong, Seong‐Jun Han, Jung Woo Kim, Jeong Hwan Lee, Subin Jeon, Youngmin Kim, Gunuk Wang, Hanul Min, Do Kyung Hwang   +14 more
wiley   +1 more source

Nanoparticle-Based Strategies to Enhance the Efficacy of STING Activators in Cancer Immunotherapy [PDF]

Yi Qiao,1,* Lingyu Wei,2,* Yinjie Su,1 Qinyuan Tan,3 Xuecheng Yang,1 Shengxian Li1 1Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 2Department of Gynecologic Oncology, Sun Yat-Sen ...
Yang X, Qiao Y, Li S, Su Y, Wei L, Tan Q
core  

Cardiovascular diseases crossroads: cGAS-STING signaling and disease progression [PDF]

It is now widely accepted that inflammation is critical in cardiovascular diseases (CVD). Here, studies are being conducted on how cyclic GMP-AMP synthase (cGAS), a component of innate immunity's DNA-sensing machinery, communicates with the STING ...
Khan, Shahid Ullah, Khan, Munir Ullah, Khan, Muhammad Shehzad, Saeed, Sumbul, Khan, Safir Ullah, Shan Ahmad, Rafi u, Ahmad, Rafi U Shan, Harlina, Putri Widyanti, Tayyeb, Jehad Zuhair, Suleman, Muhammad, Crovella, Sergio   +10 more
core   +1 more source