Results 341 to 350 of about 233,089 (385)

Progress Update on STING Agonists as Vaccine Adjuvants. [PDF]

Vaccines (Basel)
Shen Y, Huang W, Nie J, Zhang L.
europepmc   +1 more source

Extracellular vesicles from diverse fungal pathogens induce species-specific and endocytosis-dependent immunomodulation. [PDF]

PLoS Pathog
Kwaku GN, Jensen KN, Simaku P, Floyd DJ, Saelens JW, Reardon CM, Ward RA, Basham KJ, Hepworth OW, Vyas TD, Zamith-Miranda D, Nosanchuk JD, Vyas JM, Brown Harding H.   +13 more
europepmc   +1 more source

Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory. [PDF]

Nat Commun
Timilsina S, Huang JY, Abdelfattah N, Medina D, Singh D, Abdulsahib S, Subbarayalu P, Do TP, Venkata PP, Nirzhor S, Prochnau J, Bhandari M, Zheng S, Chen Y, Huang G, Mukherjee N, Hromas R, Sung P, Kaklamani V, Vadlamudi R, Zhang N, Rao MK.   +21 more
europepmc   +1 more source

Epithelial <i>Atg5</i> Deficiency Intensifies Caspase-11 Activation, Fueling Extracellular mtDNA Release to Activate cGAS-STING-NLRP3 Axis in Macrophages During <i>Pseudomonas</i> Infection. [PDF]

MedComm (2020)
Wang J, Zhang L, Liu Y, Liu Y, Xiong A, Ran Q, He X, Wong VKW, Combs C, Li G, Wu M.   +10 more
europepmc   +1 more source

STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy. [PDF]

Adv Sci (Weinh)
Gehrcken L, Deben C, Smits E, Van Audenaerde JRM.   +3 more
europepmc   +1 more source

Deubiquitinase USP13 alleviates doxorubicin-induced cardiotoxicity through promoting the autophagy-mediated degradation of STING. [PDF]

Acta Pharm Sin B
Lin L, Han J, Xu D, Fang Z, Ye B, Qian J, Han X, Min J, Long X, Wu G, Liang G.   +10 more
europepmc   +1 more source

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Multifunctional Mesoporous Polydopamine‐Based Systematic Delivery of STING Agonist for Enhanced Synergistic Photothermal‐Immunotherapy

Advanced Functional Materials, 2023
The therapeutic application of STING agonists in various malignancies has been limited by factors such as the inability of systemic administration and the immunosuppressive tumor microenvironment. Herein, this work reports a mesoporous polydopamine‐based
Wenfeng Zeng, Zimu Li, Qili Huang, Chendi Ding, Li Yang, Wenyan Wang, Zhao-Yu Shi, Yao Yang, Hongzhong Chen, Lin Mei, Xiaowei Zeng   +10 more
semanticscholar   +1 more source

STING or Sting: cGAS-STING-Mediated Immune Response to Protozoan Parasites

Trends in Parasitology, 2020
Emerging evidence suggests that the DNA-sensing pathway plays a crucial role in innate immunity against multiple diseases, especially infectious diseases. Cyclic GMP-AMP synthase (cGAS), as a DNA sensor, and stimulator of interferon (IFN) genes (STING), as an adaptor protein, are the central components that link DNA sensing to immunologic functions ...
Yifan Sun, Yang Cheng
openaire   +3 more sources

Tumor Microenvironment‐Responsive Nanoparticles Amplifying STING Signaling Pathway for Cancer Immunotherapy

Advances in Materials, 2023
Insufficient activation of the stimulator of interferon genes (STING) signaling pathway and profoundly immunosuppressive microenvironment largely limits the effect of cancer immunotherapy.
Dan Liu, Shuang Liang, Kongshuo Ma, Qian-Fang Meng, Xingang Li, Jian Wei, Mengli Zhou, Kaiqing Yun, Yuanwei Pan, L. Rao, Xiaoyu Chen, Zhaohui Wang   +11 more
semanticscholar   +1 more source