Results 131 to 140 of about 28,952 (292)

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

A novel deep learning technique for medical image analysis using improved optimizer

Health Informatics Journal
Application of Convolutional neural network in spectrum of Medical image analysis are providing benchmark outputs which converges the interest of many researchers to explore it in depth.
Vertika Agarwal, MC Lohani, Ankur Singh Bist   +2 more
doaj   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Stochastic gradient descent optimisation for convolutional neural network for medical image segmentation. [PDF]

Open Life Sci, 2023
Nagendram S, Singh A, Harish Babu G, Joshi R, Pande SD, Ahammad SKH, Dhabliya D, Bisht A.   +7 more
europepmc   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

A SIEVE STOCHASTIC GRADIENT DESCENT ESTIMATOR FOR ONLINE NONPARAMETRIC REGRESSION IN SOBOLEV ELLIPSOIDS. [PDF]

Ann Stat, 2022
Zhang T, Simon N.
europepmc   +1 more source

Nonparametric budgeted stochastic gradient descent

, 2016
One of the most challenging problems in kernel online learning is to bound the model size. Budgeted kernel online learning addresses this issue by bounding the model size to a predefined budget.
V Nguyen (9860309), TD Nguyen (9887741), T Le (13415748), D Phung (13323141)   +3 more
core  

Convergence of Hyperbolic Neural Networks Under Riemannian Stochastic Gradient Descent

We prove, under mild conditions, the convergence of a Riemannian gradient descent method for a hyperbolic neural network regression model, both in batch gradient descent and stochastic gradient descent.
Wang, Bao, Whiting, Wes, Xin, Jack
core   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Random coordinate descent: A simple alternative for optimizing parameterized quantum circuits

Physical Review Research
Variational quantum algorithms rely on the optimization of parameterized quantum circuits in noisy settings. The commonly used back-propagation procedure in classical machine learning is not directly applicable in this setting due to the collapse of ...
Zhiyan Ding, Taehee Ko, Jiahao Yao, Lin Lin, Xiantao Li   +4 more
doaj   +1 more source