Results 41 to 50 of about 117,134 (268)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Journal of Inequalities and Applications, 2021 In this paper, we investigate the existence uniqueness of mild solutions for a class of ψ-Caputo fractional stochastic evolution equations with varying-time delay driven by fBm, which seems to be the first theoretical result of the ψ-Caputo fractional ...
Min Yang
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Randomness in the Hybrid Modeling and Simulation of Insulin Secretion Pathways in Pancreatic Islets
Tsinghua Science and Technology, 2015 Insulin secreted by pancreatic islet β-cells is the principal regulating hormone of glucose metabolism. Disruption of insulin secretion may cause glucose to accumulate in the blood, and result in diabetes mellitus.
Yang Pu +3 more
doaj +1 more source
Measure, Stochasticity, and the Density of Hard Languages
SIAM Journal on Computing, 1993 Ogiwara and Watanabe have recently shown that the hypothesis P ¿ NP implies that no (polynomially) sparse language is =Pbtt-hard for NP. Their technique does not appear to allow significant relaxation of either the query bound or the sparseness criterion.
Jack H. Lutz, Elvira Mayordomo
openaire +4 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Active Learning Strategy for Surrogate-Based Quantile Estimation of Field Function
Applied Sciences, 2022 Uncertainty quantification is widely used in engineering domains to provide confidence measures on complex systems. It often requires to accurately estimate extreme statistics on computationally intensive black-box models.
Loïc Brevault +2 more
doaj +1 more source
On the measurable stochastic process
Proceedings of the Physico-Mathematical Society of Japan. 3rd Series, 1941 Not ...
openaire +2 more sources