Results 51 to 60 of about 3,057,682 (305)
Randomness in the Hybrid Modeling and Simulation of Insulin Secretion Pathways in Pancreatic Islets
Tsinghua Science and Technology, 2015 Insulin secreted by pancreatic islet β-cells is the principal regulating hormone of glucose metabolism. Disruption of insulin secretion may cause glucose to accumulate in the blood, and result in diabetes mellitus.
Yang Pu +3 more
doaj +1 more source
Measure, Stochasticity, and the Density of Hard Languages
SIAM Journal on Computing, 1993 Ogiwara and Watanabe have recently shown that the hypothesis P ¿ NP implies that no (polynomially) sparse language is =Pbtt-hard for NP. Their technique does not appear to allow significant relaxation of either the query bound or the sparseness criterion.
Jack H. Lutz, Elvira Mayordomo
openaire +4 more sources
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Active Learning Strategy for Surrogate-Based Quantile Estimation of Field Function
Applied Sciences, 2022 Uncertainty quantification is widely used in engineering domains to provide confidence measures on complex systems. It often requires to accurately estimate extreme statistics on computationally intensive black-box models.
Loïc Brevault +2 more
doaj +1 more source
Shearer’s Measure and Stochastic Domination of Product Measures [PDF]
Journal of Theoretical Probability, 2012 Let G=(V,E) be a locally finite graph. Let \vec{p}\in[0,1]^V. We show that Shearer's measure, introduced in the context of the Lovasz Local Lemma, with marginal distribution determined by \vec{p} exists on G iff every Bernoulli random field with the same marginals and dependency graph G dominates stochastically a non-trivial Bernoulli product field ...
openaire +5 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
On the measurable stochastic process
Proceedings of the Physico-Mathematical Society of Japan. 3rd Series, 1941 Not ...
openaire +2 more sources
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source