Results 51 to 60 of about 3,152,040 (308)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Randomness in the Hybrid Modeling and Simulation of Insulin Secretion Pathways in Pancreatic Islets
Tsinghua Science and Technology, 2015 Insulin secreted by pancreatic islet β-cells is the principal regulating hormone of glucose metabolism. Disruption of insulin secretion may cause glucose to accumulate in the blood, and result in diabetes mellitus.
Yang Pu +3 more
doaj +1 more source
Journal of Inequalities and Applications, 2021 In this paper, we investigate the existence uniqueness of mild solutions for a class of ψ-Caputo fractional stochastic evolution equations with varying-time delay driven by fBm, which seems to be the first theoretical result of the ψ-Caputo fractional ...
Min Yang
doaj +1 more source
Measure, Stochasticity, and the Density of Hard Languages
SIAM Journal on Computing, 1993 Ogiwara and Watanabe have recently shown that the hypothesis P ¿ NP implies that no (polynomially) sparse language is =Pbtt-hard for NP. Their technique does not appear to allow significant relaxation of either the query bound or the sparseness criterion.
Jack H. Lutz, Elvira Mayordomo
openaire +4 more sources
Model uncertainty stochastic mean-field control
, 2019 We consider the problem of optimal control of a mean-field stochasticdifferential equation (SDE) under model uncertainty. The model uncertaintyis represented by ambiguity about the law LðXðtÞÞ of the stateX(t) at time t.
Agram, Nacira, +2 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
A second-order stochastic dominance portfolio efficiency measure [PDF]
, 2008 summary:In this paper, we introduce a new linear programming second-order stochastic dominance (SSD) portfolio efficiency test for portfolios with scenario approach for distribution of outcomes and a new SSD portfolio inefficiency measure.
Chovanec, Petr, Kopa, Miloš
core
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Active Learning Strategy for Surrogate-Based Quantile Estimation of Field Function
Applied Sciences, 2022 Uncertainty quantification is widely used in engineering domains to provide confidence measures on complex systems. It often requires to accurately estimate extreme statistics on computationally intensive black-box models.
Loïc Brevault +2 more
doaj +1 more source