Results 61 to 70 of about 11,667,970 (301)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
STOCHASTIC XSL TRANSFORMATION METHOD
Безопасность информационных технологийA stochastic transformation is an unpredictable transformation of information. It is used, for example, in implementing a feedback function or an output function of a pseudorandom number generators intended for solving information security problems. This
Mikhail A. Ivanov +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Application of Finite Volume Method to Structural Stochastic Dynamics
Advances in Mechanical Engineering, 2013 The stochastic dynamic problems were becoming more difficult after considering the influences of stochastic factors and the complexity of the dynamic problems.
Weidong Chen +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source
A Model-Based Stochastic Augmented Lagrangian Method for Online Stochastic Optimization
MathematicsIn this paper, we focus on online stochastic optimization problems in which random parameters follow time-varying distributions. In each round t, a decision is obtained from solving the current optimization problem.
Zewei Wang, Dan Xue, Yujia Zhai, Cong Li
doaj +1 more source
Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig +9 more
wiley +1 more source
Stochastic time–frequency-entropy feature extraction method [PDF]
AIP AdvancesEntropy-based feature extraction methods have shown marked effectiveness across various fields. However, entropy measures are susceptible to noise interference and typically consider only time-domain information, which leads to suboptimal feature ...
Yuxing Li, Jingyi Li, Qingxu Wang
doaj +1 more source
Observer‐Based Adaptive Event‐Triggered Tracking Control for Fuzzy TS Systems With Premise Mismatch
International Journal of Adaptive Control and Signal Processing, EarlyView.This paper presents an adaptive logistic event‐triggered observer‐based tracking controller for Takagi‐Sugeno fuzzy systems under constrained inputs and network delays. Leveraging a hybrid LMI and Secretary Bird Optimization approach, this strategy significantly minimizes communication overhead and computational burden while ensuring optimal reference ...
Oussama Djadane +3 more
wiley +1 more source