Results 31 to 40 of about 174,675 (218)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Some New Results Related to the Likelihood Ratio and the Laplace Transform Ordering
MathematicsThe purpose of this paper is twofold. First, we aim to study some new properties and relations for the likelihood ratio order. In particular, we present new integral inequalities involving the ratio of two probability density functions and the ratio of ...
Abdulaziz Alenazi
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
IEEE Access, 2021 In this paper, a high order disturbance observer based stochastic adaptive anti-disturbance control algorithm has been designed for the space unmanned systems (SUSs) with high dynamic disturbances and stochastic uncertainties.
Yao Zhang +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source
MathematicsMany modern engineering systems, such as offshore wind turbines, rely on k-out-of-n configurations to ensure reliability. These systems are exposed to both internal deterioration and external shocks, which can significantly impact operational efficiency ...
Mizuki Kasuya, Lu Jin
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Order and stochastic dynamics in Drosophila planar cell polarity. [PDF]
PLoS Computational Biology, 2009 Cells in the wing blade of Drosophila melanogaster exhibit an in-plane polarization causing distal orientation of hairs. Establishment of the Planar Cell Polarity (PCP) involves intercellular interactions as well as a global orienting signal. Many of the
Yoram Burak, Boris I Shraiman
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Synchronization of Fractional Stochastic Chaotic Systems via Mittag-Leffler Function
Fractal and Fractional, 2022 This paper is involved with synchronization of fractional order stochastic systems in finite dimensional space, and we have tested its time response and stochastic chaotic behaviors.
T. Sathiyaraj +2 more
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