Results 181 to 190 of about 3,581,558 (296)

Deep Learning‐Driven Discovery and Engineering of an Efficient PETase for Depolymerization and Detoxification of PET Microplastics Under Physiological Conditions

Advanced Science, EarlyView.
A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang, Shijie He, Yuheng Chang, Sheng Mao, Jianan Canal Li, Binbin Chen, Hongxun Gao, Mingchun Xu, Chenxu Liu, Yajie Wang   +9 more
wiley   +1 more source

Block Sampler and Posterior Mode Estimation for Asymmetric Stochastic Volatility Models (Published in "Computational Statistics and Data Analysis", 52-6, 2892-2910. February 2008. ) [PDF]

This article introduces a new efficient simulation smoother and disturbance smoother for asymmetric stochastic volatility models where there exists a correlation between today`s return and tomorrow`s volatility.
Toshiaki Watanabe, Yasuhiro Omori
core  

Modeling the role of fertilizers and improved seeds on rice productivity in Tanzania using a stochastic simulation approach. [PDF]

PLoS One
Kadigi IL, Kagata L, Sieber S.
europepmc   +1 more source

A novel stochastic simulation approach enables exploration of mechanisms for regulating polarity site movement. [PDF]

PLoS Comput Biol, 2021
Ramirez SA, Pablo M, Burk S, Lew DJ, Elston TC.   +4 more
europepmc   +1 more source

Polymer Concepts in Cellular Function

Advanced Science, EarlyView.
Miao Yu, Shikha Dhiman, Dorothee Dormann, Frauke Gräter, Katja Luck, Friederike Schmid, Andreas Walther, Edward A. Lemke   +7 more
wiley   +1 more source

A Site‐Aware Representation Learning Framework For Unified Molecular Interaction Modeling and Generative Design

Advanced Science, EarlyView.
MolDBG is a site‐aware, sequence‐only framework that unifies drug‐target affinity prediction, binding‐site identification, and affinity‐conditioned molecular generation for structured proteins. Guided by multi‐task binding‐site supervision, it aligns interaction‐critical residues before learning drug‐target representations and simultaneously infers ...
Gang Luo, Qianqian Zhang, Chenhao Wang, Zhiheng Yi, Alex Jinpeng Wang, Jing Tang, Min Li   +6 more
wiley   +1 more source

Large-scale stochastic simulation of open quantum systems. [PDF]

Nat Commun
Sander A, Fröhlich M, Eigel M, Eisert J, Gelß P, Hintermüller M, Milbradt RM, Wille R, Mendl CB.   +8 more
europepmc   +1 more source

Training Image Free High-Order Stochastic Simulation Based on Aggregated Kernel Statistics. [PDF]

Math Geosci, 2021
Yao L, Dimitrakopoulos R, Gamache M.
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Stochastic simulation of breakeven cost distributions for mortality-reducing interventions in feedlot cattle. [PDF]

J Anim Sci
Horton LM, Schroeder TC, Streeter MN, Bryant LK, Hutcheson JP, Renter DG.   +5 more
europepmc   +1 more source