Results 91 to 100 of about 1,281,244 (316)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Fishery Management Enforcement Gradients to Achieve Fishery Goals

Fishes
Marine protected areas (MPAs) can allow some fish populations to rebuild within their borders in areas impacted by overfishing, but the effectiveness of reserves is highly dependent on how effectively fishing mortality is controlled, which in turn ...
Kendra A. Karr, Fabián Pina-Amargós, Tamara Figueredo-Martín, Yunier Olivera-Espinosa   +3 more
doaj   +1 more source

Development of a whole life cycle cost model for electrification options on the UK rail system [PDF]

, 2016
Projects to deliver Overhead Line Equipment (OLE) electrification on the UK rail infrastructure system presents technical challenges which the rail industry in Britain have not traditionally had to consider.
Baguley, Paul, Giuntini, L., Kirkwood, Leigh   +2 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Analysis of the contribution of the Netherlands commercial CPUE data to ICES stock assessments in the years 1995 - 2000 [PDF]

, 2003
The contribution of the Dutch commercial CPUE data to the stock assessments of North Sea plaice and sole in the years 1995-2000 has been analysed. The CPUE series are based on the total landings at age in the Dutch beam trawl fishery and the total effort
Bolle, L.J., Pastoors, M.A.
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim, Han Gil Seo, Roh‐Eul Yoo, Byung‐Mo Oh   +3 more
wiley   +1 more source

Organizational Form and Insurance Company Performance: Stocks versus Mutuals [PDF]

One unusual feature of the U.S. property-casualty insurance industry is the coexistence of stock and mutual companies. This paper explores the performance of these forms in the industry through a dynamic assessment of how mutual and stock insurance ...
Patricia Born, Richard J. Zeckhauser, W. Kip Viscusi, William M. Gentry   +3 more
core  

A catch-free stock assessment model with application to goliath grouper (Epinephelus itajara) off southern Florida [PDF]

, 2006
Many modern stock assessment methods provide the machinery for determining the status of a stock in relation to certain reference points and for estimating how quickly a stock can be rebuilt. However, these methods typically require catch data, which are
Eklund, Anne-Marie, Porch, Clay E., Scott, Gerald P.   +2 more
core