Results 81 to 90 of about 265,143 (318)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A New Deep-water Snailfish, Paraliparis anomalus (Teleostei: Liparidae) from the Western North Pacific off Honshu, Japan

Species Diversity
A new deep-water snailfish, Paraliparis anomalus, is described from two specimens collected off eastern Honshu Island, Japan (635–687 m depth). It can be distinguished from congeners by the following combination of characters: vertebrae 67 (9 + 58), a ...
Kenta Murasaki, Yoshiaki Kai, Ryo Misawa, Yoji Narimatsu   +3 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Assessment of stock, spatial distribution, and recruitment of walleye pollock in the northern and eastern Bering Sea

Известия ТИНРО, 2016
Abundance and biomass of walleye pollock Theragra chalcogramma in the Bering Sea exceeded the mean values in 2015 owing to the high-abundant year-classes of 2008 and 2012 and several medium-abundant year-classes (of 2006, 2009-2011, 2013, and 2014).
Mikhail A. Stepanenko, Elena V. Gritsay
doaj   +1 more source

Small-scale fisheries of San Miguel Bay, Philippines: biology and stock assessment [PDF]

Small scale fisheries, Fishery biology, Fishery resources, Stock assessment, Collected papers, San Miguel Bay, Philippines,
Mines, A.N. (eds.), Pauly, D.
core  

Stock assessment of the Torres Strait Spanish mackerel fishery [PDF]

, 2006
Objectives: 1. To retrieve and collate all available biological, historical fisheries, and commercial non-indigenous and Islander catch and effort data on the Torres Strait Spanish mackerel fishery. 2.
Begg, Gavin A., O'Neill, Michael F., Rose, Darren, Chen, Carla C.M.   +3 more
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

State of the stock and features of the fishery for arabesque greenling Pleurogrammus azonus Jordan at Metz (1913) in the waters of southern Kuril Islands

Известия ТИНРО, 2016
Dynamics of commercial stock is considered for arabesque greenling at southern Kuril Islands on the data on size-age structure of its catches and fishery statistics for 1974-2015.
Alexander O. Zolotov, Rafael N. Fatykhov
doaj   +1 more source

Stock assessment of Australian herring

, 2000
Australian herring (Arripis georgiana) is an important finfish resource to both the commercial and recreational sectors in Western Australia and South Australia.
D. Fairclough, Ayvazian, S.G., Jones, G.K., Fairclough, D., S. G. Ayvazian, Wise, B.S., G. K. Jones, B. S. Wise, Potter, I.C., I. C. Potter, Dimmlich, W.F., W. F. Dimmlich   +11 more
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