Results 51 to 60 of about 234,544 (269)

Records of the Rare Flabby Whalefishes Cetomimus hempeli and Gyrinomimus bruuni (Teleostei: Beryciformes) from Japan

Species Diversity
Two genera of the poorly known family Cetomimidae (flabby whalefishes), Cetomimus Goode and Bean, 1895 and Gyrinomimus Parr, 1934, are morphologically similar but differ in jaw tooth row (indistinct diagonal rows in Cetomimus vs.
Ryo Misawa, Atsuki Inuzuka, Kunihiro Fujiwara, Makoto Furusho, Fumihito Tashiro, Munehiro Takami, Yoshiaki Kai   +6 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A New Deep-water Snailfish, Paraliparis anomalus (Teleostei: Liparidae) from the Western North Pacific off Honshu, Japan

Species Diversity
A new deep-water snailfish, Paraliparis anomalus, is described from two specimens collected off eastern Honshu Island, Japan (635–687 m depth). It can be distinguished from congeners by the following combination of characters: vertebrae 67 (9 + 58), a ...
Kenta Murasaki, Yoshiaki Kai, Ryo Misawa, Yoji Narimatsu   +3 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Assessment of stock, spatial distribution, and recruitment of walleye pollock in the northern and eastern Bering Sea

Известия ТИНРО, 2016
Abundance and biomass of walleye pollock Theragra chalcogramma in the Bering Sea exceeded the mean values in 2015 owing to the high-abundant year-classes of 2008 and 2012 and several medium-abundant year-classes (of 2006, 2009-2011, 2013, and 2014).
Mikhail A. Stepanenko, Elena V. Gritsay
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

State of the stock and features of the fishery for arabesque greenling Pleurogrammus azonus Jordan at Metz (1913) in the waters of southern Kuril Islands

Известия ТИНРО, 2016
Dynamics of commercial stock is considered for arabesque greenling at southern Kuril Islands on the data on size-age structure of its catches and fishery statistics for 1974-2015.
Alexander O. Zolotov, Rafael N. Fatykhov
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source