Results 51 to 60 of about 265,143 (318)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Characterizing the composition of commercial black sea bass (Centropristis striata) catch and discards in the Mid-Atlantic and southern New England regions

Frontiers in Marine Science
Black sea bass (Centropristis striata) is an abundant fishery species that occupies continental shelf waters from the Gulf of Mexico to the Gulf of Maine.
Hannah J. Verkamp, Elizabeth A. Soranno, N. David Bethoney   +2 more
doaj   +1 more source

Considering Other Consumers: Fisheries, Predators, and Atlantic Herring in the Gulf of Maine

Ecology and Society, 2003
After decades of overexploitation and severe depletion, Atlantic herring stocks in waters of the northeastern United States have recovered. Fishery managers now consider the herring resource to be underexploited.
Andrew J. Read, Carrie R. Brownstein
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Evaluation of a spatiotemporal index standardization method for coastal shark species; implications for future stock assessments

Frontiers in Marine Science
IntroductionMethods combining data from spatially limited, independently conducted surveys indicate a preliminary recovery for coastal shark species along the Atlantic.
Kaitlyn A. O’Brien, John K. Carlson, Enric Cortés, William B. Driggers, Bryan S. Frazier, Robert J. Latour   +5 more
doaj   +1 more source

Stock assessment of the peacock bass Cichla temensis (Humboldt, 1821), an important fishing resource from the middle Negro river, Amazonas, Brazil [PDF]

Brazilian Journal of Biology
Peacock bass Cichla temensis is an important species at the Amazon basin, since commercial, subsistence and recreational fisheries simultaneously exploit it.
C. P. Campos, M. F. Catarino, C. E. C. Freitas   +2 more
doaj   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Importance of near-bottom oceanographic data in modeling the distribution of eulachon bycatch in the U.S. West Coast shrimp trawl fishery

Frontiers in Marine Science
IntroductionSpecies distribution models (SDMs) are increasingly used in fisheries science to understand species’ spatial patterns and improve stock assessments.
Leif K. Rasmuson, Leif K. Rasmuson, Scott D. Groth, Christopher A. Edwards, Eric S. Anderson, Matthew T.O. Blume, Kendall R. Smith   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Stock assessment and fishery management of the pink shrimp Farfantepenaeus brasiliensis Latreille, 1970 and F. paulensis Pérez-Farfante, 1967 in Southeastern Brazil (23° to 28° S)

Brazilian Journal of Biology
Quantitative analyses of the pink shrimp (Farfantepenaeus brasiliensis and Farfantepenaeus paulensis) fisheries were carried out using data collected from July 1999 to July 2001 from the trawling operations of the fishing fleet based in Santos/Guarujá ...
N. O. Leite Jr., M. Petrere Jr.
doaj   +1 more source