Results 51 to 60 of about 1,281,244 (316)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Population dynamics and fishery biology of the yellow-edged lyretail grouper Variola louti (Forsskål, 1775) along the eastern coast of the Red Sea

Frontiers in Marine Science
The yellow-edged lyretail grouper, Variola louti, is ecologically and commercially important in the Red Sea. As a carnivorous species, V. louti plays a vital role in maintaining coral reef ecosystem health. Annually, an estimated 260 tonnes of V.
Sirajudheen Thayyil Kadengal, Zahra Okba, Goutham Bharathi Muthu Palani, Santhosh Charles, Adel M. S. Adam, Nesrine Boulila, Eyüp Mümtaz Tıraşın, Eyüp Mümtaz Tıraşın, Mark Dimech   +8 more
doaj   +1 more source

Stock assessment of the gulf menhaden, Brevoortia patronus, fishery [PDF]

, 1987
A stock assessment of the gulf menhaden. Brevoortia patronus, fishery was conducted with data on purse-seine landings from 1946 to 1985 and port sampling data from 1964 to 1985.
Vaughan, Douglas S.
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The East Atlantic and Mediterranean bluefin tuna stock management: uncertainties and alternatives

Scientia Marina, 2003
Although the Atlantic bluefin tuna has been studied for more than a century, the assessment of the East stock is characterised by a large amount of uncertainty.
Jean-Marc Fromentin
doaj   +1 more source

Vulnerability assessment of urban building stock: a hierarchic approach [PDF]

, 2012
In the last decades the evaluation of the seismic risk are of rising concern, considered essential in the activity and definition of strategy planning and urban management.
Costa, A., Ferreira, T., Mendes da Silva, J. A. R., Varum, H., Vicente, R.   +4 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Careproctus io (Teleostei: Liparidae), a New Snailfish from the Western North Pacific, with Comments on Generic Limits

Species Diversity
The new snailfish Careproctus io is described on the basis of three specimens collected from the western North Pacific, off northeastern Honshu Island, Japan.
Yoshiaki Kai, Eisuke Morikawa, Ryo Misawa   +2 more
doaj   +1 more source

Coded-Wire Tag Expansion Factors for Chinook Salmon Carcass Surveys in California: Estimating the Numbers and Proportions of Hatchery-Origin Fish

San Francisco Estuary and Watershed Science, 2013
Recovery of fish with adipose fin clips (adc) and coded-wire tags (cwt) in escapement surveys allows calculation of expansion factors used in estimation of the total number of fish from each adc,cwt release group, allowing escapement to be resolved by ...
Michael S. Mohr, William H. Satterthwaite   +1 more
doaj