Results 51 to 60 of about 1,331,584 (301)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Media Sentiment, Government Supervision Strategy, and Stock Price Fluctuation Risk

open access: yesDiscrete Dynamics in Nature and Society, 2021
From the cross perspective of communication science and administration management, based on complex network theory, this paper constructs a model of stock price fluctuation risk contagion, which comprehensively considers media sentiment and government ...
Zhu Jufang
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan   +6 more
wiley   +1 more source

Analysis of factors affecting stock prices in mining sector: Evidence from Indonesia Stock Exchange [PDF]

open access: yesManagement Science Letters, 2019
The stock prices of mining companies are affected by several factors, such as world oil price, inflation, exchange rate, and Price to Earnings Ratio (PER), political affairs, basic metal prices, etc.
Zakia Maulida Antono   +2 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

The Impact of Oil Price Fluctuations on Stock Markets in Developed and Emerging Economies [PDF]

open access: yes
This study examines the response of stock markets to oil price volatilities in Japan, Singapore, Korea and Malaysia by applying the generalized impulse response and variance decomposition analyses to the monthly data spanning 1986:01 – 2011:02.
Thai-Ha LE, Youngho CHANG
core   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Analisis Kausalitas Antara Harga Saham Konvensional Dengan Harga Saham Syariah Di Indonesia (pendekatan granger causality)

open access: yesEl-Jizya: Jurnal Ekonomi Islam, 2018
Stock Price that occur in the share market always fluctuate over time. Stock value fluctuations will be set by the strength of supply and demand. If the supply amount is greater than the amount of demand, generally the exchange stock value will decrease,
Wartoyo Ayus Ahmad Yusuf
doaj   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

ANALISIS PENGARUH FAKTOR FUNDAMENTAL EKONOMI MAKRO DAN HARGA MINYAK TERHADAP SAHAM LQ45 DALAM JANGKA PENDEK DAN JANGKA PANJANG

open access: yesJournal of Indonesian Applied Economics, 2012
The objective of this research was to examine the macro economics factors and theprice of crude oil that influencing LQ45 stock price in the short and long run.
Dwi Wahyu Prasetiono
doaj   +1 more source

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