Results 151 to 160 of about 7,321 (222)

Towards standardized patient reported physical function outcome reporting: linking ten commonly used questionnaires to a common metric. [PDF]

Qual Life Res, 2019
Oude Voshaar MAH, Vonkeman HE, Courvoisier D, Finckh A, Gossec L, Leung YY, Michaud K, Pinheiro G, Soriano E, Wulfraat N, Zink A, van de Laar MAFJ.   +11 more
europepmc   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

The Psychometric Properties of an Internet-Administered Version of the Depression Anxiety and Stress Scales (DASS) in a Sample of Dutch Adults. [PDF]

J Psychopathol Behav Assess, 2018
Wardenaar KJ, Wanders RBK, Jeronimus BF, de Jonge P.   +3 more
europepmc   +1 more source

New Efficient and Practicable Adaptive Designs for Calibrating Items Online. [PDF]

Appl Psychol Meas, 2020
He Y, Chen P, Li Y.
europepmc   +1 more source

Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging

Advanced Science, EarlyView.
Cell death is important in both the development and treatment of cancer. In this study, it is demonstrated for the first time that a specific measurement of the transmembrane water exchange rate using magnetic resonance imaging can be used as an early marker of cell death in mammalian cells, in animals and in human patients. Abstract Cell death plays a
Athanasia Kaika, Luca Nagel, Ulrike Höckendorf, Bangwen Xie, Geoffrey J. Topping, Mathias Schillmaier, Irina Beer, Frits H. A. van Heijster, Julian Rauch, Tristan A. Kuder, Sandra Sühnel, Bernd Erber, Christian Lohrmann, Simone Ballke, Thomas Metzler, Katja Steiger, Philipp J. Jost, Natalia P. Ivleva, Philipp Paprottka, Jonathan Nadjiri, Kevin M. Brindle, Wolfgang A. Weber, Franz Schilling   +22 more
wiley   +1 more source

Diversity in Irish and British avifauna assemblages: What can variation in diversity profiles reveal about the forces that drive assemblage composition and structure? [PDF]

Ecol Evol
Groh C, Siriwardena GM, McMahon BJ.
europepmc   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

Programmable Klebsiella pneumoniae Phage Tropism Enabled by Scalable Receptor‐Binding Protein Mining and Modular Assembly

Advanced Science, EarlyView.
This work introduces a scalable, data‐driven strategy that turns the vast sequence diversity of phage receptor‐binding proteins into modular tools for engineering customizable phages. By clustering and experimentally validating diverse RBPs, the authors build an accurate map linking sequence to host specificity and create plug‐and‐play modules that ...
Shisong Jing, Yiyao Song, Xianbiao Bi, Yuqin Song, Dawei Wei, Jiangqing Huang, Yuan Zeng, Gang Zhang, Rong Zhang, Chao Wang, Jie Feng   +10 more
wiley   +1 more source

Practical Consequences of Item Response Theory Model Misfit in the Context of Test Equating with Mixed-Format Test Data. [PDF]

Front Psychol, 2017
Zhao Y, Hambleton RK.
europepmc   +1 more source

PROMIS® Pediatric Depressive Symptoms as a Harmonized Score Metric. [PDF]

J Pediatr Psychol, 2020
Kaat AJ, Kallen MA, Nowinski CJ, Sterling SA, Westbrook SR, Peters JT.   +5 more
europepmc   +1 more source