Results 31 to 40 of about 7,321 (222)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Penyetaraan Tes Uan: Mengapa dan Bagaimana? [PDF]
, 2008 Debates concerningwhat is right and what is wrOng with national finalexamination (UAN) in Indonesiaare not new. National Final Examination (UAN),a significant processusing a test form to measure learning output, has beendeveloped to provide useful ...
SukimoDS, S. (SukimoDS)
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FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
The Secret Life of the Della Cruscan Sonnet: William Gifford's Baviad and Maeviad [PDF]
, 2007 In the past few decades, feminist critics have conveniently regarded the sonnet as a fundamentally masculine genre, as a bulwark of male subjectivity and a site of female objectification.
Van Remoortel, Marianne
core +2 more sources
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
Barnes Hospital Bulletin [PDF]
, 1979 https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1161/thumbnail ...
core +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Oat variety characteristics for suppressing weeds [PDF]
, 2012 Oats are a valuable food source and useful in the crop rotation both in organic and conventional farming systems, partly because of their excellent weed suppression ability. Thomas Döring, Louisa Winkler and Nick Fradgley report new results that show how
Döring, Thomas F. +2 more
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