Results 41 to 50 of about 3,274,016 (229)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Modeling item banking: Analysis and design of a computerized system. [PDF]

, 2008
Los tests adaptativos informatizados dependen de la existencia de bancos de ítems de los que seleccionar los ítems más adecuados a aplicar a lo largo de la administración del test.
Molina Ibáñez, Jesús Gabriel, Pareja Montoro, Ignacio, Sanmartín, Jaime   +2 more
core   +1 more source

Vom Instrument zum Konstrukt - standardisierte Messung gesundheitsbezogener Lebensqualität [PDF]

, 2020
Die Erhebung patientenberichteter Endpunkte ist in klinischer Forschung und Versorgung gleichermaßen relevant. Die gegenwärtig genutzten Instrumente zur Erhebung dieser Endpunkte sind allerdings wenig standardisiert, was die Vergleichbarkeit der ...
Fischer, Herbert Felix
core   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

The effect of organic farming systems on aspects of the environment - desk study OF0123 [PDF]

, 1995
Key Conclusions 1. The crop rotations of organic systems maintain landscape diversity and biodiversity whilst the maintenance of field boundaries on organic units produces benefits to a wide range of organisms. 2. Inorganic nitrogen fertilisation and
Bailey, Steven, Bell, Barbara, Keatinge, Ray, Shepherd, Mark, Unwin, Roger, Webb, John   +5 more
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Oat variety characteristics for suppressing weeds [PDF]

, 2012
Oats are a valuable food source and useful in the crop rotation both in organic and conventional farming systems, partly because of their excellent weed suppression ability. Thomas Döring, Louisa Winkler and Nick Fradgley report new results that show how
Döring, Thomas F., Fradgley, Nick, Winkler, Louisa   +2 more
core  

Management, regulation and environmental impacts of nitrogen fertilization in northwestern Europe under the Nitrates Directive; a benchmark study [PDF]

, 2012
Implementation of the Nitrates Directive (NiD) and its environmental impacts were compared for member states in the northwest of the European Union (Ireland, United Kingdom, Denmark, the Netherlands, Belgium, Northern France and Germany).
A. Hart, A.-K. Techen, B. Fraters, B. H. Jacobsen, B. Osterburg, F. Vertès, G. Hofman, H. F. M. ten Berge, H. J. M. van Grinsven, J. P. Lesschen, J. Webb, K. G. Richards, P. Durand, S. T. J. Lalor, T. Dalgaard, W. J. Willems   +15 more
core   +5 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source