Results 41 to 50 of about 363,479 (303)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Monsters in the Night: Hannibal, Prodigia, and the Parallel Worlds of Epode 16 and Ode 4.4
, 2016 Item does not contain ...
Stocks, C.A., Claire Stocks
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
CONSIDERATIONS ON STOCK OPTIMIZATION [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2019 In order to carry out its activity in optimum conditions and achieve its goal, either to develop a product, to do a job or perform a service, any entity must maintain a balanced level of stocks of raw materials and materials.
MARIA-ANDREIA ILIESCU (RISTEA) +1 more
doaj
Stock Liquidity and Stock Return
Ekspektra : Jurnal Bisnis dan Manajemen, 2019 This study aims to examine and analyze the effect of stock liquidity on stock returns on manufacturing companies listed on the Indonesia Stock Exchange. This study uses two control variables namely size and age and the study period from 2013 to 2017.
openaire +3 more sources
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Investment performance of Jakarta Islamic Index (JII) stocks. [PDF]
, 2015 The objective of this study is to assess comprehensively the investment performance, trading activity and volatility of Jakarta Islamic Index (JII) stocks.
Listyaningsih, Erna
core
Quantification of C and N stocks in grassland topsoils in a Dutch region dominated by dairy farming
, 2011 Estimates on soil organic carbon (SOC) and nitrogen (N) stocks in soils cannot be directly calculated from routine soil analyses, since these often lack measurements on soil bulk density (Bd).
Sonneveld, M.P.W. +1 more
core +1 more source