Results 51 to 60 of about 114,313 (264)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
STOICHIOMETRY: LINKING ELEMENTS TO BIOCHEMICALS [PDF]
Ecology, 2004 Ecological stoichiometry is a useful tool for studying how the elemental composition of organisms and their food affects production, nutrient cycling, and food- web dynamics. Two analyses are presented here that show that the use of simple element ratios in stoichiometric calculations may in certain circumstances prove inadequate because of the ...
Anderson, T.R. +2 more
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FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Diversity, 2022 In the last several decades, overgrazing has led to various changes in the plant communities, soil nutrients and soil microbial communities in alpine Kobresia meadows, which contain various plant communities coexisting on the Qinghai–Tibet Plateau ...
Li Lin +8 more
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YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
, 2014 Stoichiometry is the branch of chemistry that deals with reacting amounts. It can be used to describe the amount of chemical present and also to predict the how much product is formed in a reaction. Central to stoichiometry is the SI unit of the amount of substance—the mole—which is defined using Avogadro's number.
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Acta Limnologica Brasiliensia, 2019 Justus von Liebig observed that one could greatly increase agricultural yields by adding relatively small quantities of nitrogen (N), phosphorus (P) and potassium (K) to soils. This finding led to the most recent agricultural revolution. But because most
James Bryan Cotner
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Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
The use of SEM/EDS method in mineralogical analysis of ordinary chondritic meteorite
Geologija, 2009 The aim of this study was to evaluate the potential of scanning electron microscopy coupled with energy dispersiveX-ray spectroscopy (SEM/EDS) for determination of mineral phases according to their stoichiometry and assessment of mineral composition of ...
Breda Mirtič, Urša Curk, Miloš Miler
doaj
Stoichiometry on the edge—humans induce strong imbalances of reactive C:N:P ratios in streams
Environmental Research Letters, 2023 Anthropogenic nutrient inputs led to severe degradation of surface water resources, affecting aquatic ecosystem health and functioning. Ecosystem functions such as nutrient cycling and ecosystem metabolism are not only affected by the over-abundance of a
Alexander Wachholz +8 more
doaj +1 more source