Results 131 to 140 of about 1,092,982 (283)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Diet of the weasel in Hungary [PDF]

, 2007
The diet of weasel (Mustela nivalis) collected in agricultural mosaic plain regions of Hugary was studied using the analysis of stomach and rectum contents (n = 155).
Heltai, Miklós, Lanszki, József
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Efficacy of cimetidin in the prevention of ulcer formation in the stomach during immobilization stress [PDF]

The effect of stress on the formation of ulcers in the mucous membrane of the stomach, the increase in cyclic adenosine monophosphate level in the gastric tissues, and parietal cell structure alteration.
Dorofeyev, G. I., Gavrovskaya, L. K., Ivashkin, V. T., Litovskiy, I. A.   +3 more
core   +1 more source

Zooplankton-fish interactions in the littoral zone of Nyanza Gulf, Lake Victoria [PDF]

, 1999
Samples of zooplankton and fish were collected from six sampling points in Nyanza Gulf, Lake Victoria in Kenya from June to December 1998, using 76 mu m memo-filament mesh size strainer and an 80 mu m mesh size plankton net.
Owili, M.
core  

Luteolin suppresses cell migration and invasion via targeting miR-6809-5p/FLOT1/FAK and eliciting EMT in hepatocellular carcinoma

Translational Oncology
Luteolin, 3′,4′,5,7-tetrahydroxyflavone, a natural flavonoid component found in various Chinese herbs such as Scutellaria barbata D. Don, honeysuckle, chrysanthemum, schizonepeta, and ajuga decumbens, exhibits potential for cancer prevention and therapy.
Pei-Wei Yang, Su-Ping Ma, Xin-Ju Chen, Fang-Ming Yang, Shou-Mei Wang, Qian Wang, Shu-Hui Zhang   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Metabolic Comparison of One-Anastomosis Gastric Bypass, Single-Anastomosis Duodenal-Switch, Roux-en-Y Gastric Bypass, and Vertical Sleeve Gastrectomy in Rat [PDF]

, 2018
Background One-anastomosis gastric bypass (OAGB) and single-anastomosis duodenal switch (SADS) have become increasingly popular weight loss strategies. However, data directly comparing the effectiveness of these procedures with Roux-en-Y gastric bypass ...
Arble, Deanna M., Bozadjieva, Nadajda, Evers, Simon S., Frikke-Schmidt, Henriette, Lewis, Alfor, Myronovych, Andriy, Seeley, Randy J., Toure, Mouhamadoul Habib   +7 more
core   +1 more source

Interventional study of guided musical-imagination training in patients with chronic obstructive pulmonary disease complicating with anxiety

Asian Journal of Surgery, 2023
Ping Li, Yan-Ping Huang
doaj   +1 more source

Chaihuang Qingyi Huoxue granule ameliorates severe acute pancreatitis by modulating gut microbiota and repairing the intestinal mucosal barrier

Frontiers in Cellular and Infection Microbiology
BackgroundDuring severe acute pancreatitis (SAP), damage to the intestinal mucosal barrier and translocation of intestinal pathogenic bacteria are key mechanisms that accelerate the disease progression of SAP.
Xiaobin Zhang, Xusen Zeng, Wen Guo, Xin Zhou, Xin Zhou, Yi Zhang, Mingyun Tang, Juan Fu, Yuqing Deng, Xin Liang, Long Zhao, Zhi Li, Zhi Li, Zhi Li, Tiangang Wang, Li Li, Guohui Xiao   +16 more
doaj   +1 more source