Results 91 to 100 of about 5,007,261 (301)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Endoscopic Mucosal Resection for Esophageal and Gastric Mucosal Cancers
Canadian Journal of Gastroenterology, 1998 Accumulated data from surgically resected specimens reveal that mucosal cancers of the esophagus and stomach pose low risk of lymph node metastasis.
Haruhiro Inoue
doaj +1 more source
Patologìâ, 2013 Introduction In Ukraine the rate of gastric cancer is 23 cases per 100 thousand of population. Despite the stable decrease in morbidity and mortality, this pathology continues to be in the top five most common malignancies among men and in the ...
O. M. Levyk, K. V. Barannikov
doaj +1 more source
Metal polishing, stomach cancer, and clearing houses [PDF]
, 1988 Rhiannon Jones
openalex +1 more source
International Journal of Innovative Science and Research TechnologyGastric cancer is an important health problem and is the fourth most common cancer and the second leading cause of cancer-related deaths worldwide. The incidence of stomach cancer is increasing and it can be dealt with using new methods in prediction and
Seyed Masoud Ghoreishi Mokri +2 more
semanticscholar +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Stomach and duodenal ulcer as a cause of death in patients with cancer: a cohort study
International Journal of Emergency MedicineIntroduction Non-cancer deaths are now becoming a significant threat to the health of cancer patients. Death from stomach and duodenal ulcer is linked to cancer due to the side effects of treatment and its pathogenesis.
Ramez M. Odat +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Increased stomach cancer risk following radiotherapy for testicular cancer
British Journal of Cancer, 2014 Background:Abdominal radiotherapy for testicular cancer (TC) increases risk for second stomach cancer, although data on the radiation dose–response relationship are sparse.Methods:In a cohort of 22 269 5-year TC survivors diagnosed during 1959–1987 ...
M. Hauptmann +26 more
semanticscholar +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source