Results 81 to 90 of about 161,240 (242)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Gastric pH and Stomach Contents

open access: yesAnesthesia & Analgesia, 1993
Peter G. Atanassoff   +2 more
openaire   +4 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Partial trophic segregation in co-occurring Gambusia species (Cyprinodontiformes: Poeciliidae) in a natural wetland of Cuba/ Segregación trófica parcial entre especies de Gambusia (Cyprinodontiformes: Poeciliidae) en un humedal natural de Cuba

open access: yesRevista de Investigaciones Marinas, 2019
Gambusia punctata and Gambusia puncticulata show a distinctive distribution pattern in Cuba: G. punctata dominates mountain streams, whereas G. puncticulata is more abundant in lowland wetlands.
Sheila Rodríguez-Machado   +9 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Contenido estomacal de Spondylus leucacanthus (Bivalvia: Spondylidae) y su relación con la temporada de reproducción y la abundancia de fitoplancton en Isla Danzante, Golfo de California

open access: yesRevista de Biología Tropical, 2001
Durante 1994 se recolectaron especímenes de S. leucacanthus en Isla Danzante, Golfo de California, se registró la temperatura superficial y del agua del fondo, se tomaron muestras del contenido estomacal y del fitoplancton en el medio, la época de ...
Ma. del Socorro Muñetón-Gómez   +2 more
doaj  

Analysis of food habits of skate Rioraja agassizii (Elasmobranchii, Rajidae) from southern Brazil

open access: yesBrazilian Journal of Biology
Catches and exports of skate Rioraja agassizii place this species as “vulnerable to extinction” on the IUCN Red List; therefore, biological and ecological knowledge becomes an important instrument for its conservation control.
N. S. Motta   +4 more
doaj   +1 more source

Stomach cancer and soil metal content [PDF]

open access: yesBritish Journal of Cancer, 1982
R, Philipp, A O, Hughes, M C, Robertson
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

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