Results 81 to 90 of about 491,125 (334)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Chaihuang Qingyi Huoxue granule ameliorates severe acute pancreatitis by modulating gut microbiota and repairing the intestinal mucosal barrier

Frontiers in Cellular and Infection Microbiology
BackgroundDuring severe acute pancreatitis (SAP), damage to the intestinal mucosal barrier and translocation of intestinal pathogenic bacteria are key mechanisms that accelerate the disease progression of SAP.
Xiaobin Zhang, Xusen Zeng, Wen Guo, Xin Zhou, Xin Zhou, Yi Zhang, Mingyun Tang, Juan Fu, Yuqing Deng, Xin Liang, Long Zhao, Zhi Li, Zhi Li, Zhi Li, Tiangang Wang, Li Li, Guohui Xiao   +16 more
doaj   +1 more source

Лучевая диагностика пептических язв и их осложнений [PDF]

, 2012
Проаналізовані клініко-рентгенологічні дослідження 250 хворих, які прооперовані з приводу виразкової хвороби шлунку і дванадцятипалої кишки, поліпозу, раку шлунку і захворювань ободової кишки.
Крадинов, А.И., Черноротов, В.А., Черноротова, Е.В.   +2 more
core  

Hempelian and Kuhnian approaches in the philosophy of medicine: the Semmelweis case [PDF]

, 2005
Semmelweis?s investigations of puerperal fever are some of the most interesting in the history of medicine. This paper considers Hempel?s (1966) analysis of the Semmelweis case.
Gillies, DA
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Psychometric validation of the Chinese version of the Short Inflammatory Bowel Disease Questionnaire and evaluation of its measurement invariance across sex

Health and Quality of Life Outcomes, 2021
Background This study aimed to evaluate the psychometric properties of the Chinese version of the Short Inflammatory Bowel Disease Questionnaire (C-SIBDQ), and its measurement invariance across sex in Chinese patients with inflammatory bowel disease (IBD)
Dajuan Sun, Lili Chi, Jiahui Liu, Junwei Liang, Song Guo, Shaojie Li   +5 more
doaj   +1 more source

Crohn's disease of the stomach and duodenum [PDF]

Gut, 1970
Clinical and radiological abnormalities in 12 patients with gastroduodenal involvement were encountered amongst 300 patients followed by one of us between 1944 and 1969. Symptoms of dyspepsia were relatively mild and obstructive symptoms when present were readily relieved by bypass surgery. The patients have been followed for a mean of 9.7 years (range
J. F. Fielding, D. K. M. Toye, W. T. Cooke, D. C. Beton   +3 more
openaire   +3 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Uncovering the Multitarget Therapeutic Mechanism of Tong-Xie-Yao-Fang on Irritable Bowel Syndrome

Journal of Food Quality
Background. This study investigated the pharmacological mechanisms of Tong-Xie-Yao-Fang (TXYF) against irritable bowel syndrome (IBS). Methods. The chemical profile of TXYF was identified through UHPLC-QTOF-MS.
Xiangxue Ma, Jinke Huang, Haomeng Wu, Xia Li, Fengyun Wang, Xudong Tang   +5 more
doaj   +1 more source

DISTRIBUTION, DIET, AND PREVALENCE OF AMPHIBIAN CHYTRID FUNGUS IN NON-NATIVE AMERICAN BULLFROGS (LITHOBATES CATESBEIANUS) AT THE VALENTINE NATIONAL WILDLIFE REFUGE, NEBRASKA, USA [PDF]

, 2014
American Bullfrogs (Lithobates catesbeianus) have been widely introduced beyond their native range in North America and can negatively affect organisms in wetland environments via a suite of mechanisms including interspecific interactions and disease ...
Geluso, Keith, Kerby, Jacob L., Lingenfelter, Alyx R., Nenneman, Melvin P., Peterson, Brian C.   +4 more
core   +2 more sources