Results 121 to 130 of about 91,023 (291)

Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β

open access: yesAdvanced Biology, EarlyView.
This study presents an optogenetic approach for graded clustering of eGFP‐fused proteins using an eGFP‐specific nanobody and engineered Cryptochrome 2 variants. The method enables potent, reversible activation of NF‐κB signaling via endogenous pathways, as confirmed by RNA sequencing. This versatile system provides a spatially and temporally controlled
Alexandra Anna Maria Fischer   +8 more
wiley   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

open access: yesAdvanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio   +11 more
wiley   +1 more source

Cancer: second cause of death among the elderly in Medellín, 2002-2006

open access: yesRevista Facultad Nacional de Salud Pública, 2012
Objective: to describe the behavior of lung, stomach, andprostate cancer mortality among the elderly in the city of Medellinfrom 2002 to 2006. Methodology: a descriptive study with asecondary information source.
Luz M. Bustamante A   +2 more
doaj  

Case analysis of 24 cases of Oxyntic gland neoplasm of the stomach [PDF]

open access: green
Xinyuan Xie   +4 more
openalex   +1 more source

Metachronous Multiple Primary Malignant Neoplasms of the Stomach and the Breast: Report of Two Cases With Review of Literature [PDF]

open access: bronze, 2014
Vilvapathy Senguttuvan Karthikeyan   +6 more
openalex   +1 more source

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

open access: yesAdvanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav   +5 more
wiley   +1 more source

Stool Microbiota Composition Differs in Patients with Stomach, Colon, and Rectal Neoplasms [PDF]

open access: hybrid, 2018
Omar Youssef   +12 more
openalex   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

open access: yesAdvanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li   +10 more
wiley   +1 more source

Gastroenteroanastomosis (GEA): Method of choice in the advanced stomach cancer in older age [PDF]

open access: yesArchive of Oncology, 2002
Kocić Miomir   +4 more
doaj   +1 more source

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