Results 71 to 80 of about 151,181 (304)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Gastrointestinal stroma tumor of the stomach
Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2016 The gastrointestinal stroma tumor is an infrequent type of tumor of mesenchymal origin called sarcoma. It appears in the wall of the digestive lobe, the stomach, the small intestine, the colon, the esophagus and occasionally in the omentum, mesenteric ...
Jaime Landell Cruz +1 more
doaj
H. pylori induced chronic gastritis: a pathway to gastric mucosa associated lymphoid tissue lymphoma; review of current diagnostic and treatment modalities [PDF]
Microbiota in Health and DiseaseMALT-type marginal zone lymphomas are B-cell neoplasms that include extra-nodal tissues and exhibit a slow clinical course. The stomach is the predominant area, and most people are afflicted with Helicobacter pylori.
R. Tirumalareddy +5 more
doaj +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
The Synchronous Prevalence of Colorectal Neoplasms in Patients with Stomach Cancer [PDF]
, 2011 Ryung‐Ah Lee
openalex +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A Large Gastric Inflammatory Fibroid Polyp
GE: Portuguese Journal of Gastroenterology, 2015 Inflammatory fibroid polyp (IFP) is an unusual benign gastrointestinal subepithelial tumor (SET). The endosonographic (EUS) features of IFPs were sporadically reported on imaging tips or small case series study.
Teresa Pinto-Pais +7 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Gut and Liver, 2016 Background/AimsAlthough LIN28A is known to potentially play a role in the oncogenesis of various cancers, whether LIN28A expression is a predictor of poor prognosis in patients with gastric cancer has not been fully explored.
Chan Hyuk Park +4 more
doaj +1 more source