Results 31 to 40 of about 2,553,893 (339)

Hacı Bayram Veli’nin Şiirlerinde İnsanın İkilemi

Tasavvuf İlmi ve Akademik Araştırma Dergisi, 2023
Anadolu tasavvuf geleneğinde günümüzde yadsınamaz derecede önem taşıyan şahsiyetlerden biri de Hacı Bayram Veli’dir. Tasavvufi kurum ve ekoller açısından farklı akisleri olan Hacı Bayram Veli’nin Türk toplumunun ürettiği farklı kültürel enstrümanlarda da
Musa Kaval
doaj  

Mass balance, metabolic disposition, and pharmacokinetics of a single IV dose of [14C]CA102N in HT-29 xenograft athymic nude mice

Frontiers in Pharmacology
IntroductionCA102N is a novel anticancer drug developed by covalently linking H-Nim (N-(4-Amino-2-phenoxyphenyl methanesulfonamide) to Hyaluronic Acid to target CD44 receptor-rich tumors.
Eskouhie Tchaparian, Hua-Yang Lin, Yuchih Chen, J. Neil Hunter, Sindy Yin, Huey Ng, Albert Wu, Albert Wu   +7 more
doaj   +1 more source

Le Trône de Grâce : étude et la restauration d’une Trinité lorraine du XVe siècle

CeROArt : Conservation, Exposition, Restauration d'Objets d'Art, 2010
The restoration of the Trône de Grâce including to a diploma of the end of studies was the opportunity to realize the remove of the twelve overpaints recovering the the original polychromy layer.
Muriel Oiry
doaj   +1 more source

The Soft Side of Stone: Notes for a Phenomenology of Stone [PDF]

, 2007
Stone represents the firmness and intransigence of the world within which we live and act. But beyond the perception and appropriations of stone, diverse meanings lie hidden between the hardness of stone and its uses.
Berleant, Arnold
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Towards a Taxonomy Machine: A Training Set of 5.6 Million Arthropod Images

Data
The taxonomic identification of organisms from images is an active research area within the machine learning community. Current algorithms are very effective for object recognition and discrimination, but they require extensive training datasets to ...
Dirk Steinke, Sujeevan Ratnasingham, Jireh Agda, Hamzah Ait Boutou, Isaiah C. H. Box, Mary Boyle, Dean Chan, Corey Feng, Scott C. Lowe, Jaclyn T. A. McKeown, Joschka McLeod, Alan Sanchez, Ian Smith, Spencer Walker, Catherine Y.-Y. Wei, Paul D. N. Hebert   +15 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Gritty sensation on catheter: A new clinical sign for self-diagnosis of stone formation in the continent urinary pouch

Indian Journal of Urology, 2010
With more experience and better management, the incidence of complications like stone formation after continent urinary diversion is uncommon today.
Apul Goel, Anuj Goel, Diwakar Dalela, S N Sankhwar   +3 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source